Comparação dos parâmetros do estresse oxidativo e marcadores inflamatórios de pacientes com DPC e tabagistas

Abstract

Chronic lung disease (CLD) are diseases present in lower airway. The CLD is a progressive inflammatory condition of the lower airways where the symptoms arise from abnormal inflammatory response of the lungs to inhaled noxious particles or gases, and the principal causes smoking. The inflammatory response of the airways has received special attention, with the mechanisms described on the pathogenesis of this response. Oxidative stress and reactive oxygen species have been suggested in the pathogenesis of bronchiectasis and chronic obstructive pulmonary disease including disabling symptoms leading to physical inactivity and deconditioning. Thus, the present study aimed to compare the oxidative stress and inflammatory status of patients with CLD and smokers and their association with variables of respiratory muscle strength, functional capacity and quality of life. The sample consisted of 21 voluntary and 7 with CLD and 14 smokers. The main results showed differences between the groups for the variables of FVC (p <0.003) and FEV1% (p <0.006) compared respiratory muscle strength was a difference between groups of MIP (p <0.043) and MEP (p <0.026), quality of life on the physical health item differ between groups (p <0.001). In relation to oxidative stress showed an increase in TBARS (p <0.001) in smokers compared with CLD, the Cat (p <0.002) marker showed high values in CLD group and CRP (p <0.001) differed between groups. These results can conclude that the levels of oxidative stress were higher in the smokers than in relation to the CLD, showing that inhalation of toxic gases such as cigarette smoke, raises the levels of oxidative stress.