Síntese de 1-(selenobutil)-2-fenil-4H-selenofeno[2,3-c]cromenos via reação de ciclização mediada por sais de ferro

Abstract

This paper reports the study developed for the preparation of 1-(butylselanyl)-2-phenyl-4H-selenopheno[2,3-c]chromenes substituted by cyclization in intramolecular cascade of arylpropargyl ethers. Firstly, the study was carried out to obtain the best reaction condition, subjecting substrates 1 to the intramolecular cyclization mediated by FeCl3 and dibutyl diselenete (BuSeSeBu), which allowed the synthesis of selenofeno [2,3-c] chromenes 2. A methodology proved to be effective for a variety of substrates, being able to provide seven new products in good to moderate yield under mild reaction conditions.