Síndrome hepatorrenal como consequência da hepatite lobular dissecante em dois cães

Abstract

The lobular dissecting hepatitis is characterized by the occurrence of hepatic and nodular fibrosis withacquired portosystemic shunts. It commonly occurs in young dogs with chronic hepatitis whose evolution is fast and the etiology unknown. This article aims to describe the clinical signs, laboratory findings and clinical complications of two large male dogs, six and eight months of age, with postmortem diagnosis of dissectinglobular hepatitis. The clinical signs were severe ascites, anorexia, vomiting and absence of defecation.The blood count indicated the presence of non-regenerative anemia and thrombocytopenia and the serumbiochemical evaluation,on both dogs, there was an increased activity of alkaline phosphatase and hypoalbuminemia. The analysis of the abdminal effusion was consistent with pure transudate. During the abdominal ultrasound, the occurrence of hepatomegaly and portosystemic shunts was noticed. The hepatorenal syndrome was noticed on the dogs which were observed in this report, and it has contributed to the worsening of manifested clinical signs. We conclude that lobular dissecting hepatitis should be included in the differential diagnosis list of young dogs showing signs of pure transudate ascites, refractory to medical treatment. It is also possible to conclude that the hepatorenal syndrome occurs in lobular dissectinghepatitis, contributing to the unfavorable evolution of the disease.