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Itens para a visualização no momento 11-19 of 19
Ação neuroprotetora e anti-inflamatória do disseleneto de difenila e exercício de natação em modelo de envelhecimento em ratos
(Universidade Federal de Santa Maria, 2016-01-29)
Aging is a degenerative process that affects virtually all living organisms. The increase in the inflammatory process seems to be one of the main factors that contribute to aging and inflammaging and neuroinflammation in ...
Ação farmacológica do 4,4’-dicloro-difenil disseleneto em modelos de hiperglicemia e obesidade em ratos
(Universidade Federal de Santa Maria, 2017-03-03)
The obesity epidemic is a worldwide public health problem and is considered one of the leading causes of death and disability worldwide. This is because the pathophysiology of this disease is extremely complex and involves ...
Desenvolvimento de nanocápsulas contendo disseleneto de bis (p-metoxifenila): biodistribuição e efeitos em modelos de dor em camundongos
(Universidade Federal de Santa Maria, 2017-08-11)
The chronic pain is a global public health problem and its pharmacological management is still unsatisfactory. The identification of novel molecules to effectively treat chronic pain states remains a major objective in ...
Estudo comparativo de β-selenoaminas e disselenetos em modelos hepatotóxico e alternativo
(Universidade Federal de Santa Maria, 2017-08-17)
Organic selenium compounds, Ebselen and diphenyl diselenide (DPDS), possess numerous characteristics such as, antioxidant activity, anti-inflammatory among others. In this regard, new molecules have been produced through ...
Avaliação dos efeitos de calcogenonucleosídeos derivados da zidovudina usando células sanguíneas como alvo toxicológico
(Universidade Federal de Santa Maria, 2018-02-23)
Zidovudine (AZT), a thymidine derivative, is widely used in antiretroviral regimens and more recently it has been indicated, in combination with other chemotherapeutics, for the treatment of some types of cancer. Patients ...
Síntese e atividades antioxidante e antitumoral de 5´-arilseleno azidotimidina
(Universidade Federal de Santa Maria, 2012-03-30)
The synthesis of compounds that use a nucleoside as the base structure, has an intense field application. Among these compounds, the most known nowadays is azydothymidine or zidovudine, a drug which was first synthesized ...
3-(4-Fluorofenilselenil)-2,5 difenilselenofeno produz ação do tipo-antidepressiva em diferentes modelos de depressão em camundongos
(Universidade Federal de Santa Maria, 2014-03-11)
Selenophenes are a promising class of heterocyclic selenium-containing compounds
presenting important pharmacological properties. Based on selenium well-described role on
mood regulation and since depression is a serious ...
Efeitos dos compostos de selênio e zinco nas lesões gastrointestinais induzidas por etanol em ratos
(Universidade Federal de Santa Maria, 2012-03-30)
Gastric ulcer is a world widespread illness that affectes a great number of people and it is correlated to life style, food intake, alcohol and smoke in association or not to stress behavior. The lesions are in association ...
Disseleneto de p-metoxi fenila atenua o prejuízo cognitivo e a injúria cerebral em um modelo da doença de Alzheimer em roedores
(Universidade Federal de Santa Maria, 2012-09-17)
Alzheimer s disease (AD) is a progressive neurodegenerative disorder, mainly characterized by memory and intellectual capacity loss. AD is characterized by deposition of amyloid-β peptide, neurofibrillary tangles, ...