Associação entre biomarcadores oxidativos, inflamatórios e de disfunção endotelial em pacientes obesos

Abstract

Obesity is a world phenomenon caracterized as a cronic metabolic disorder, where the excess of adipose tissue is responsable for oxidative stress, inflammation and endothelial dysfunction states. Due the higher number of obese people and the mortality due pathologies associated to obesity, studies that contibute to the prevention and monitoring are important. So, the study of oxidative stress, inflammatory and endothelial dysfunction biomarkers that dectect earlier damages caused by obesity can contibute to its better physiopathology understanding, such as its diagnosis and monitoring. In this work the study population was constituted by obese and overweight subjects and healthy control. The main objectives from this work were, in the study population: evaluate the behavior from some oxidative stress markers malondialdehyde (MDA), ischemia-modified albumin (IMA), advanced oxidation protein products (AOPP) and plasma thiol ( SH); evaluate the proinflammatory citokine interleukin-6 (IL-6) levels; determine the laboratory marker levels related to the endothelial dysfunction nitric oxide (NO) and albuminury and investigate the behavior from lipidic and glicemic biomarkers, such as the prevalente of diabetes mellitus and hypertension. The obese subjects compared with the others studied subjects presented: higher levels of MDA, IMA and AOPP, showing a lipidic and proteic oxidation (mainly the albumin protein); increasing of IL-6 levels that caracterize a significative proinflammatory state; lower levels of NOx with consequent NO bioavailability reduction and increasing of albuminury, reflecting a probable endothelial dysfunction; discrete HDL cholesterol levels reduction and increasing of glucose, such as higher prevalence of diabetes and hypertension. Therefore, considering the obtained results, we observed that the obese subjects presented changes related to oxidative, inflammatory and vascular processes, showing that the evaluation of biomarkers associated with these processes has a great importance to better understanding of obesity physiopathology that avoid related pathologies and their consequent mortality.