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O papel do polimorfismo Ala16Val da Mn-SOD no acidente vascular encefálico crônico: um estudo clínico
(Universidade Federal de Santa Maria, 2019-08-17)
Considered one of the most common neurological diseases, stroke has a high morbidity and mortality, and corresponds to 85% of disease cases. Several factors are involved in disease etiology, such as changes in vascular ...
ATP como modulador do sistema purinérgico e inflamação e status redox em pacientes com melanoma
(Universidade Federal de Santa Maria, 2019-09-16)
Melanoma is a type of skin cancer, formed in melanocytes, cells that produce the pigment melanin. The melanocytes of the epidermis are the most common places of melanoma’s origin; however, it can be also developed in ...
Efeitos da oxima butano-2,3-dionatiossemicarbazona frente ao dano testicular causado por cádmio em camundongos
(Universidade Federal de Santa Maria, 2014-03-06)
We investigated the action of butane-2,3-dione thiosemicarbazone oxime against the testicular damage caused by cadmium chloride (CdCl2) in mice swiss adult male. The animals received a single injection of CdCl2 at the dose ...
Envolvimento do estresse oxidativo e dos sistemas colinérgico e purinérgico na esclerose múltipla: estudo clínico e de revisão
(Universidade Federal de Santa Maria, 2018-02-23)
Multiple sclerosis (MS) is one of the main chronic inflammatory diseases of the central nervous system
(CNS) that cause functional disability in young adults. It is considered one complex autoimmune and
neurodegenerative ...
Oleorresina de copaíba apresenta atividade antinociceptiva tópica em um modelo de queimadura de pele induzido por radiação UVB em camundongos
(Universidade Federal de Santa Maria, 2020-11-27)
Burn injuries are common worldwide, representing a major public health problem responsible for more than 180,000 deaths annually. These injuries can be caused by several factors, including ultraviolet (UV) radiation. ...
Fibras musculares oxidativas e glicolíticas apresentam resposta inflamatória e alterações bioenergéticas peculiares após uma contusão musculoesquelética em ratos
(Universidade Federal de Santa Maria, 2021-02-19)
Muscle contusion represents a type of stress that disrupts cell homeostasis. Characterized by traumatic lesion, that impair the availability of oxygen (O2) in the tissue, promotes an increase in the production of reactive ...
Influência farmacogenética da enzima SOD2 na resposta in vitro ao resveratrol de células mononucleares
(Universidade Federal de Santa Maria, 2014-10-03)
Resveratrol (RES) is an anti-aging molecule that provides both anti-inflammatory and antioxidant properties. However, it is unclear whether the basal oxidative state of the cell has any influence on the effects of this ...
Frutose-1,6-bisfosfato e N-acetilcisteína atenuam a formação de produtos proteicos de oxidação avançada, uma nova classe de mediadores inflamatórios, in vitro
(Universidade Federal de Santa Maria, 2012-09-19)
The assessment of biomarkers of reactions involving reactive oxygen species have the
potential not only to determine the extent of oxidative damage, but also to predict the
effectiveness of therapeutic strategies aimed ...
Atividade de ectoenzimas e de colinesterases e biomarcadores de estresse oxidativo em pacientes com câncer de pulmão
(Universidade Federal de Santa Maria, 2012-03-02)
Lung cancer has become one of the most commonly diagnosed neoplastic diseases, as well as one of the most lethal worldwide, characterized, therefore, as a public health problem. This spread of lung cancer in the world ...
Envolvimento do receptor de potencial transitório anquirina 1 e efeito farmacológico da diosmetina na queimadura de pele induzida pela radiação UVB em camundongos
(Universidade Federal de Santa Maria, 2021-05-11)
Excessive exposure to type B ultraviolet radiation (UVB) can lead to several changes to the skin resulting from the oxidative and inflammatory processes installed through the neuronal and non-neuronal receptors activation. ...