Uso do stanozolol no colapso das vias brônquicas: relato de caso

Abstract

Collapse of exclusively bronchial pathways in dogs is rarely reported in the literature, as most studies focus on tracheal collapse. There is no specific and curative treatment, but only therapies and recommendations focused on clinical signs. Thus, the treatment is considered frustrating for both the owner and the veterinarian. Stanozolol is a drug with anabolic properties, capable of promoting tissue growth, stimulating chondrocytes and increasing the synthesis of collagen and chondroitin sulfate however its use is poorly explored in veterinary medicine. The aim of this study is to provide a literature review about bronchial collapse, which is still poorly understood and described; and report a case of a canine with that disease, which was submitted to a clinical treatment with stanozolol for 112 days. The frequency of coughing, described by the tutors, was the main evaluation parameter, and showed a significant reduction in the first month.It remained intermediate until the end of treatment; and after that, it became accentuated again. Fortnightly hematological examinations were performed. There was an increase of Alanine Aminotransferase (ALT) enzyme, which normalized after reducing the frequency of the drug to once a day and discontinuing the concomitant use of a bronchodilator; however, it fluctuated again, for no apparent reason, later. Although it is not possible to determine the influences of frequency and dose of stanozolol and theophylline administration together, the use of this medication seems to be promising. More studies are needed to evaluate the effectiveness of this steroid in the treatment of bronchial collapse in dogs.