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Desenvolvimento e validação de método por cromatografia líquida em fase reversa para avaliação de interleucina-11 humana recombinante. Correlação com o bioensaio
(Universidade Federal de Santa Maria, 2011-07-28)
Interleukin 11 (IL-11) is a multifunctional cytokine in the IL-6 type family of long-chain
helical cytokines, which modulates the proliferation, differentiation and maturation of various types of
hematopoietic cells. ...
Desenvolvimento e validação de metodologia para análise de valdecoxibe. Avaliação de efeitos sobre parâmetros hematológicos
(Universidade Federal de Santa Maria, 2006-06-01)
Valdecoxib is a non-steroidal anti-inflammatory drug that represents a second-generation of cyclooxygenase-2 enzyme inhibitor and possesses anti-inflammatory, analgesic and antipyretic activities. In this work a reversed-phase ...
Desenvolvimento e validação de métodos cromatográficos para avaliação de interferon-alfa 2a em formulações farmacêuticas
(Universidade Federal de Santa Maria, 2009-03-17)
The interferon is a cytokine with antiviral, antiproliferative, and immunomodulatory
properties. It is a protein synthesized by cells in response to viral infection, producing successive
biochemistry alterations. The ...
Avaliação de potência de toxina botulínica tipo a por ensaios biológicos e método por cromatografia líquida em fase reversa
(Universidade Federal de Santa Maria, 2015-02-26)
Botulinum toxin type A (BTTA) is a polypeptide with 1296 amino acids and its used in some pathologies like hyperhidrosis and migraine, but the cosmetic area is the most important application. BTTA is produced from broth-culture ...
Estudo da prevalência de hemoglobina S em doadores de sangue na região de Santa Maria-RS e aconselhamento genético familiar
(Universidade Federal de Santa Maria, 2009-02-18)
The Sickle Cell Anemia is the most common monogenic hereditary disease in the
world. The cause of this disease is a changing point in the position six of the beta globin
gene for hemoglobin, changing the glutamic acid ...
Avaliação do fibrinogênio como uma nova fonte para a formação in vitro de produtos proteicos de oxidação avançada
(Universidade Federal de Santa Maria, 2015-07-08)
Oxidative stress is characterized by an imbalance between the production of free radicals, particularly reactive oxygen species (ROS), and the defense capacity of the organism against these species, leading to a progressive ...
Reposicionamento e avaliação da atividade antibacteriana e de clivagem do DNA plasmidial in vitro dos não antibióticos Anlodipino e Valsartana
(Universidade Federal de Santa Maria, 2019-12-19)
Infections caused by multiresistant microrganisms have increased considerably in recent years,
reaching approximately one fifth of worldwide mortality, becoming a public health problem. Another
worrying factor is the ...
Atividade da delta aminolevulinato desidratase sangüínea e o estresse oxidativo em pacientes hemodialisados
(Universidade Federal de Santa Maria, 2007-03-09)
The acid aminolevulinato dehydratase (δ-ALA-D) is a thiol enzyme involved in tetrapirrólicos composite biosynthesis, as heme. This enzyme is inhibited by some metals, having been also its inhibition a pointer of poisoning ...
Avaliação in vitro da atividade de antimicrobianos na cavidade bucal sobre Candida glabrata sensíveis e resistentes ao fluconazol
(Universidade Federal de Santa Maria, 2016-03-21)
Oropharyngeal candidiasis is a challenging fungal disease in the clinical setting of immunocompromised patients, either by their morbidity or by its difficulties in treatment. Patients with AIDS, cancer, and transplanted ...
Desenvolvimento e validação de métodos cromatográficos para avaliação de teor/potência de insulina glargina
(Universidade Federal de Santa Maria, 2016-03-30)
hans, and is secreted into the bloodstream. It plays and important role in regulating the
metabolic activities of the body, particularly the homeostasis of the blood glucose. Insulin
glargine is a recombinant human insulin ...