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Estudo da interação do sistema purinérgico, colinérgico e funções cognitivas na demência esporádica do tipo alzheimer: os efeitos das antocianinas
(Universidade Federal de Santa Maria, 2013-03-27)
Dementia is a brain disorder characterized by decline in several mental functions and results in deficits in memory functioning in a variety of cognitive tasks. Evidence has emerged showing that anthocyanins (ANT) possess ...
Ação convulsivante do disseleneto de difenila em ratos: estudo dos mecanismos neuroquímicos e da toxicocinética
(Universidade Federal de Santa Maria, 2010-07-27)
In recent years have been identifical numerous pharmacological properties of a selenium compound, diphenyl diselenide [(PhSe)2]. Consequently, it is important the investigation of its toxic effect for a safe application ...
Polimorfismo da Ala16Val MnSOD na hipercolesterolemia e sua associação com biomarcadores de inflamação e estresse oxidativo
(Universidade Federal de Santa Maria, 2010-03-11)
This study aimed to analyze the association between the genetic polymorphism of the manganese-dependent superoxide dismutase (Ala16Val MnSOD) and the oxidative and inflammatory markers in hypercholesterolemic and control ...
Respostas bioquímicas e fisiológicas de Cucumis sativus e Avena sativa ao estresse causado por alumínio
(Universidade Federal de Santa Maria, 2010-05-21)
Aluminum (Al) is the most abundant metal in the Earth's crust, affecting growth and development of plants. The aim of this study was to investigate the effects of Al on
seedlings of cucumber (Cucumis sativus L.) and oat ...
Mecanismos envolvidos nos efeitos do seleneto vinílico bis substituído (svbs) em modelos animais de depressão e de dor
(Universidade Federal de Santa Maria, 2011-03-18)
The association between depression and chronic pain is frequent and bidirectional. The high number of patients with depression and chronic pain who are refractory to currently available drugs makes it important search for ...
A influência do processo inflamatório nas convulsões e no déficit cognitivo induzidos pelo ácido glutárico em ratos jovens
(Universidade Federal de Santa Maria, 2011-02-04)
Glutaric acidemia type I (GA-I) is an inborn error of metabolism (EIM), characterized biochemically by major accumulation of glutaric acid (GA) and pathologically by a characteristic striatal degeneration. The clinical ...
Avaliação toxicológica de compostos orgânicos de telúrio sobre o desenvolvimento pré-natal em camundongos
(Universidade Federal de Santa Maria, 2011-03-25)
It is known that most chemical agents readily cross the placenta and thus may be considered that maternal exposure to external agents can result in toxic effects on embryo-fetal organism. Considering the chemical characteristics ...
Estudo de mecanismos de toxicidade do metilmercúrio: papel protetor de flavonóides
(Universidade Federal de Santa Maria, 2010-08-12)
Methylmercury (MeHg) is an important environmental toxicant that may cause irreversible neurobehavioral and neuropsychological disorders in humans and experimental animals. The major mechanisms of MeHg-induced toxicity ...
Investigação da atividade antioxidante in vitro e da composição química de diferentes extratos de plantas medicinais
(Universidade Federal de Santa Maria, 2011-03-18)
Oxidative stress (OS) is involved in the development of several disorders involving the central nervous system, such as Alzheimer s disease (AD). Considering the limitations of current therapeutics for AD, there is still ...
Efeitos da crioterapia em modelos de contusão e isquemia/reperfusão sanguínea em músculo de ratos
(Universidade Federal de Santa Maria, 2010-12-16)
The musculoskeletal disorders are in the most common injuries observed in individuals in the primary care, occupational health, and in sports medicine. Among these disorders, the contusion is described as a direct traumatic ...