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Estudos químicos, moleculares, microbiológicos e toxicológicos de novas moléculas eficazes contra biofilmes de pseudomonas aeruginosa e micobactérias de crescimento rápido
(Universidade Federal de Santa Maria, 2021-07-12)
It is known that microbial infections caused by microorganisms in sessile form are a more challenging issue, with regard to pathogenesis and treatment, than infections caused by planktonic microorganisms. Biofilm maturation ...
Comparação de marcadores de estresse oxidativo em sangue, colostro e cordão umbilical após parto vaginal e cesáreo
(Universidade Federal de Santa Maria, 2021-08-20)
Pregnancy is characterized as an oxidative event with physiological changes in the
body to accommodate a developing fetus. The transition from pregnancy to the
postpartum period can occur through different types of births, ...
O extrato bruto das folhas da espécie Randia ferox (Cham & Schlecht) DC. apresenta adequado perfil de segurança e potencial antineuroinflamatório in vitro
(Universidade Federal de Santa Maria, 2021-08-27)
Neuropsychiatric diseases directly affect the quality of life of those affected and their families, becoming a public health problem. Among the hypotheses of its pathophysiology, neuroinflammation has been explored, making ...
Quantificação de biomarcadores em pacientes com fibromialgia submetidos a terapia com acupuntura
(Universidade Federal de Santa Maria, 2021-03-05)
Fibromyalgia (FM) is a syndrome characterized by chronic, diffuse pain and systemic
symptoms. Its etiology and pathogenesis are still not completely understood. The
therapy used in FM mainly consists of the use of ...
Efeitos da carbamilação in vitro sobre a quantificação da albumina pelos ensaios imunoturbidimétrico e colorimétrico
(Universidade Federal de Santa Maria, 2021-11-05)
Albumin is a low-molecular-weight non-glycosylated globular protein with several functions, such as maintaining colloidal osmotic pressure and transporting various substances. It is the main protein present in plasma. ...
Estudo de métodos físico-químicos e biológico para caracterização e avaliação do anticorpo monoclonal recombinante denosumabe
(Universidade Federal de Santa Maria, 2021-10-21)
Denosumab (DmAb) is monoclonal antibody (mAb) that inhibits proliferation and activity of osteoclasts cells, that is commercially available in Brazil as Prolia® and Xgeva®, for treatment of bone diseases. Structurally, it ...
Caracterização, toxicidade, atividade antioxidante, antimicrobiana e antibiofilme do óleo essencial e extrato de Achyrocline flaccida
(Universidade Federal de Santa Maria, 2021-09-30)
Medicinal plants represent an important source of new molecules with diverse benefits and/or applications for human health. Even with the advancement of technologies, plants continue to be the best option for discovering ...
Avaliação da atividade biológica in vitro de triazenos, sertralina e metildopa como alternativas no reaproveitamento de medicamentos
(Universidade Federal de Santa Maria, 2021-04-19)
Currently, countless efforts to discover effective, selective and innovative antineoplastic and antimicrobial therapies have led to the synthesis and investigation of the biological activity of different molecules. Triazenes ...