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Efeito farmacológico do disseleneto de m-trifluormetil-fenila na comorbidade entre dor e depressão em camundongos
(Universidade Federal de Santa Maria, 2015-07-24)
Chronic pain and depression often coexist, and several mechanisms are involved in the pathogenesis of this comorbidity, which confer it resistance to treatment. The serotonergic system is considered a central mechanism in ...
Oleorresina de copaíba apresenta atividade antinociceptiva tópica em um modelo de queimadura de pele induzido por radiação UVB em camundongos
(Universidade Federal de Santa Maria, 2020-11-27)
Burn injuries are common worldwide, representing a major public health problem responsible for more than 180,000 deaths annually. These injuries can be caused by several factors, including ultraviolet (UV) radiation. ...
Papel do receptor B1 para cininas e o efeito da inibição da enzima conversora de angiotensina em ataques agudos de gota em roedores
(Universidade Federal de Santa Maria, 2014-08-20)
Gout, or gouty arthritis, has been associated of a range of comorbidities as hypertension and kidney diseases. Some studies have indicated that certain antihypertensive drugs, such as angiotensin I-converting enzyme ...
Papel das poliaminas periféricas no desenvolvimento da dor inflamatória em ratos
(Universidade Federal de Santa Maria, 2010-07-21)
Polyamines (putrescine, spermidine and spermine) are aliphatic amines produced by the action of ornithine descarboxylase (ODC), a rate-limiting and protein kinease C
(PKC)-regulated step in polyamine synthesis. Since the ...
Papel do receptor TRPV1 em um modelo articular de gota aguda em ratos
(Universidade Federal de Santa Maria, 2014-02-17)
The gout is an extremely painful type of arthritis. Despite the large number of drugs available for its treatment, they usually cause many adverse effects that limit their use. Then, further investigations are necessary ...