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Avaliação dos efeitos farmacológico e toxicológico de 4- organocalcogeno-isoquinolinas
(Universidade Federal de Santa Maria, 2014-03-12)
Monoamine oxidase (MAO) is a target enzyme in the treatment of several
pathologies, being that new molecules which inhibit of a selective, potent and
reversible manner their isoforms and without adverse effects are ...
Avaliação dos efeitos de drogas anti-adenosinérgicas e do disseleneto de difenila no prejuízo da memória e estresse oxidativo relacionados ao envelhecimento
(Universidade Federal de Santa Maria, 2012-08-08)
Biological aging is gradual and progressive decline of physical functions that begin in adulthood and ends with death in almost all animals species. One of the most common features of aging is the reduced ability to learn ...
Avaliação do efeito do disseleneto de difenila na nocicepção induzida pela administração neonatal de glutamato monossódico em ratos
(Universidade Federal de Santa Maria, 2014-09-09)
Monosodium glutamate (MSG) has been the target of research due to its toxicological effects. Neonatal administration of MSG in animals can affect the morphological and electrophysiological organization of the brain, leading ...
Avaliação do efeito inibitório do composto orgânico de selênio ebselen na atividade da enzima acetilcolinesterase cerebral de ratos in vitro
(Universidade Federal de Santa Maria, 2015-02-27)
Acetylcholinesterase (AChE) is an important regulatory enzyme that modulates cholinergic synapses by hydrolysis of acetylcholine (ACh), a neurotransmitter involved in many biological processes, especially in memory and ...
Avaliação dos mecanismos envolvidos na ação antinociceptiva causada pelo seleneto vinílico bis substituído (SVBS) em camundongos
(Universidade Federal de Santa Maria, 2009-03-24)
The interest in organoselenium biochemistry and pharmacology has increased in the last two decades due to a variety of organoselenium compounds that possess biological activity. Accordingly, bis selenide is known as a safe ...
Atividade hipolipidêmica do disseleneto de difenila na hiperlipidemia induzida por Triton WR-1339 em camundongos
(Universidade Federal de Santa Maria, 2009-11-26)
In mammals, the liver plays a central role in whole-body lipid metabolism. Unfortunately, dysregulation of these pathways has been implicated in hyperlipidemias. In recent years, a significant association between the trace ...
Efeito do tipo antidepressivo do disseleneto de difenila em um modelo de depressão induzida por malation em ratos
(Universidade Federal de Santa Maria, 2010-04-01)
Organophosphorus (OP), among them malathion, are responsible for most of the poisonings reported annually in Brazil. In addition to symptoms of cholinergic
poisoning, the exposure to OP causes affective and cognitive ...
Desbalanço superóxido-peróxido de hidrogênio versus seleno-L-metionina e castanha-do-Brasil: regulação diferencial in vitro de (seleno)enzimas
(Universidade Federal de Santa Maria, 2017-08-01)
Introduction: The coupled enzymatic reactions between the manganese-dependent superoxide dismutase (MnSOD/SOD2) and selenoenzyme glutathione peroxidase-1 (GPx-1) selenoenzyme are essential for mitochondrial redox balance ...
4,4'-dicloro-difenil disseleneto reverte o déficit de memória induzido pela corticosterona em camundongos
(Universidade Federal de Santa Maria, 2016-02-29)
Chronic stress or even a single serious traumatic experience may have a negative impact on cognitive function. In this sense, organic selenium compounds are molecules that arouse great interest because they have various ...
Selenito de sódio previne neurotoxicidade induzida por paraquat em peixe-zebra (Danio rerio)
(Universidade Federal de Santa Maria, 2016-08-26)
Considering the sodium selenite (Na2SeO3) antioxidant properties and the involvement of oxidative and nitrosative stress events in neurotoxicity induced by paraquat (PQ) herbicide, this study investigated the potential ...