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Efeito antioxidante e imunomodulador de um multissuplemento à base de guaraná, selênio e L-carnitina em modelos in vitro, in vivo e em pacientes com esclerose múltipla
(Universidade Federal de Santa Maria, 2022-08-19)
Multiple sclerosis (MS) is an autoimmune, demyelinating, and neurodegenerative disease, which has neuroinflammation and oxidative stress as key parts of its pathogenesis. Among the clinical forms of the disease, is ...
Avaliação de parâmetros de estresse oxidativo em gestantes gemelares
(Universidade Federal de Santa Maria, 2018-01-05)
Twin pregnancies are considered to be of high obstetric risk due to several morbidities frequently present due to the increased supply of metabolic compounds to fetuses and the high oxygen consumption by the fetus-placenta ...
Ação antioxidante e neuroprotetora de derivados pirazolínicos inéditos
(Universidade Federal de Santa Maria, 2008-03-28)
Oxidative stress is involved in several neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis. Oxidative stress
seems to be involved in the pathology of dementia/amnesia. ...
Efeito da casca de jabuticaba (Myrciaria jaboticaba (Vell.) Berg.) sobre estresse oxidativo e resposta inflamatória em modelo de diabetes mellitus tipo 2 em ratos
(Universidade Federal de Santa Maria, 2014-03-14)
Type 2 diabetes mellitus (DM2) is a multifactorial disease mainly characterized by metabolic disorders related to insulin. Hyperglycemia is one of the causes of excessive generation of reactive oxygen species (ROS) leading ...
17-β Estradiol e resveratrol nos parâmetros bioquímicos e hematológicos de ratas ovariectomizadas submetidas a desmielinização pelo brometo de etídio
(Universidade Federal de Santa Maria, 2012-03-05)
Among the neurodegenerative diseases those involving the demyelination of the nervous system, such as multiple sclerosis (MS) that affects young and middle-aged adults, have great importance. Thus, the goal of this study ...
Modelos de toxicidade da cisplatina em ratos adolescentes: papel protetor do disseleneto de difenila e do ebselen e avaliação da co-exposição ao estresse
(Universidade Federal de Santa Maria, 2022-04-19)
Cisplatin is a recommended chemotherapy drug for the treatment of pediatric and adult
neoplasms that, despite its wide use, is related to numerous serious adverse effects
such as neurotoxicity. In animal models using ...
Avaliação de marcadores bioquímicos, de estresse oxidativo e do efeito antioxidante da quercetina no hipotireoidismo
(Universidade Federal de Santa Maria, 2014-03-28)
Hypothyroidism is characterized by a disorder resulting from deficiency of
thyroid hormones and is related to lipid metabolism dysfunction and cardiovascular
diseases development risk. However, these changes in hypothyroidism ...
Avaliação de biomarcadores inflamatórios, oxidativos e vasculares em pacientes com hipercolesterolemia
(Universidade Federal de Santa Maria, 2011-03-21)
Hypercholesterolemia is a determining factor for the development of atherosclerosis, which is
considered the main cause of cardiovascular diseases. In Brazil, as in most developed
countries, cardiovascular diseases are ...
Associação entre biomarcadores oxidativos, inflamatórios e de disfunção endotelial em pacientes obesos
(Universidade Federal de Santa Maria, 2013-03-25)
Obesity is a world phenomenon caracterized as a cronic metabolic disorder, where the
excess of adipose tissue is responsable for oxidative stress, inflammation and endothelial
dysfunction states. Due the higher number ...
Avaliação de biomarcadores de estresse oxidativo no diabetes mellitus gestacional
(Universidade Federal de Santa Maria, 2016-07-15)
Gestational diabetes mellitus (GDM) is a glucose intolerance beginning during pregnancy. It is a common disorder and its incidence is increasing among pregnant women. Hyperglycemia derived from GDM is associated with the ...