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O papel das florestas preservadas contra os efeitos dos agrotóxicos e da radiação solar ultravioleta em girinos e o potencial de pequenas propriedades rurais na redução de impactos
(Universidade Federal de Santa Maria, 2020-03-02)
Amphibians are the most threatened group of vertebrates on the planet, declines have already been
observed in natural populations in various regions of the globe. Several hypotheses have been
proposed to elucidate this, ...
Alterações comportamentais mediadas pelo etanol em peixe-zebra: influência do estresse oxidativo, disfunção mitocondrial e modulação serotoninérgica
(Universidade Federal de Santa Maria, 2020-07-24)
Ethanol consumption is a serious public health problem due to the negative impacts that affect individuals and society. Because the mechanism of action of ethanol in the central nervous system is complex and not fully ...
Dano ao DNA induzido por fotoclivagem e análise citotóxica de uma porfirina meso-tetra-rutenada sob irradiação por luz visível
(Universidade Federal de Santa Maria, 2020-12-03)
Photodynamic Therapy (PDT) combined with the use of molecules containing the porphyrin ring associated with ruthenium transition metal has become an alternative method to the traditional treatment of melanoma. Here, we ...
Estudos in silico aplicados a compostos orgânicos de mercúrio e selênio em sistemas biológicos
(Universidade Federal de Santa Maria, 2020-08-10)
Methylmercury (MeHg) is a potent neurotoxin, which is associated with the inhibition of Glutathione Peroxidase (GPx) and Thioredoxin Reductase (TrxR) selenozymes, however, the mechanism of MeHg inhibition, at the molecular ...
Adição do óleo de Melaleuca alternifolia na dieta de peixes minimiza efeitos tóxicos causados pelo consumo diário de aflatoxina
(Universidade Federal de Santa Maria, 2020-04-09)
Mycotoxins are natural toxins produced through the secondary metabolism of toxigenic fungi. More than 400 classes of mycotoxins are found, however, as aflatoxins (AFs), produced mainly by Aspergillus species, including ...
Depressão e prejuízo de memória induzidos pela administração de estreptozotocina em camundongos: efeitos terapêuticos do disseleneto de p-clorodifenila
(Universidade Federal de Santa Maria, 2020-02-20)
Pre-diabetes and diabetes are metabolic diseases of heterogeneous etiopathology including defects in
the secretion and action of insulin, or both, the presence of hyperglycemia, glucose and insulin
intolerance, disorders ...
JM-20 como composto multialvo: avaliação do potencial antioxidante, inibidor de colinesterases e citotoxicidade
(Universidade Federal de Santa Maria, 2020-10-29)
Multi-target compounds have aroused the interest of many researchers. The main characteristic of these substances is the ability to act through different mechanisms of action, a relevant fact in cases of pathologies caused ...
Disfunção imune em indivíduos HIV positivos sob terapia antirretroviral: papel da razão CD4/CD8 e da atividade da enzima adenosina desaminase
(Universidade Federal de Santa Maria, 2021-03-31)
Human immunodeficiency virus (HIV) uncontrolled replication results in the Acquired
Immunodeficiency Syndrome (AIDS). Antiretroviral therapy (ART) reduces morbidity
and mortality but inflammation and immune activation ...
Depressão induzida pela administração de dexametasona em camundongos: efeitos terapêuticos do disseleneto de p-clorodifenila
(Universidade Federal de Santa Maria, 2020-02-19)
Different animal models already reported that the administration of DEX can induce phenotypic behaviors of depression and anxiety, as well as brain molecular changes. However, most studies report on the effects of DEX from ...
Agressividade e ansiedade induzidas pelo estresse em peixe-zebra: envolvimento da monoamina oxidase, modulação redox e alterações neuroendócrinas
(Universidade Federal de Santa Maria, 2020-07-24)
Mental disorders are considered XXI century pandemics that cause various health diseases. About a third of people have problems related to mental health worldwide. Furthermore, several disorders are triggered by exacerbated ...