Síntese de uma nova classe de moléculas derivadas do AZT: 5’- arilcalcogenil-3’-(4-fenilselenoalquil-1,2,3-triazol-1-il)-timidina com atividade antitumoral

Abstract

Abstract: This work presents the synthesis as well as the antitumor effect in vitro in bladder cancer cells 5637 of a new class of 5'-arylcalcogenyl-3'-(4-phenylselenoalkyl- 1,2,3-triazol-1-yl)-thymidine derivatives of AZT. The optimization of the reaction conditions, such as the catalyst and solvent, for the reaction of 1,3-dipolar cycloaddition in the formation of the 1,2,3-triazole heterocycle was also performed. The synthesis of the new molecules proved to be efficient, being obtained through a convergent route in good to excellent yields (68 - 94%).