Síntese, caracterização e avaliação da atividade antimicobacteriana de compostos de coordenação derivados do disseleneto de 2,2’-bis(3-aminopiridina)

Abstract

This work describes the synthesis and characterization of seven new coordination compounds derived from 2,2'-bis-(3-aminopyridine) diselenide interacting with metal ions of diferent degree of hardness. Among the seven coordination compounds, six had their structure elucidated by X-ray crystallography, beside others characterization methods, such as mass espectrometry, elemental analysis, infrared spectroscopy, UV-Vis and Raman. These complexes involve metal centers of CuI, CuII, ZnII, FeII, CoII and AgI. Of these complexes, four had exclusive coordination on the nitrogen atom, two were obtained in cluster form and one as selenium atom oxidation complex. All the complexes obtained are in accordance with Pearson's theory of acids and bases, in wich, the nitrogen atoms coordinate to harder nature metals and selenium atoms to softer nature metals. The complexes were evaluated as potential antimicobacterial agents. The antimicrobial activity of the new coordination compounds obtained from microorganisms of the genus Mycobacterium, like: Mycobacterium fortuitum, Mycobacterium massiliense e Mycobacterium abscessos presented potentiated antimicobacterial activity in relation to ligand action (L) and the metal salts used in the synthesis. The compound [Ag(3-NH2PySe)]6 (7) obtained a MIC higher than the MIC obtained for ligand (L), being 143.75 μg.ml-1. The best MIC results were obtained for [CuCl2(L)] (1) and [FeCl2(L)] (5), with MIC values of 17.46 μg.mL-1 against M. abscessus and M. massiliense for both compounds, and 35.93 μg.mL-1 against M. fortuitum, also for both compounds. The results obtained are of great importance since the microorganisms studied in this work already present resistance profile to the drugs used in the clinic.