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Quantificação da glutationa reduzida em eritrócitos humanos por cromatografia líquida de alta eficiência-uv: validação e aplicação
(Universidade Federal de Santa Maria, 2005-02-21)
Oxidative stress may be initiated by a decline in the antioxidant defence system or by an overproduction of free radicals leading to an imbalance between oxidants and antioxidants. The most significant alteration in the ...
Derivados pirazolínicos inéditos causam antinocicepção em camundongos no teste da formalina
(Universidade Federal de Santa Maria, 2004-07-29)
The discovery of pyrazole derivatives dates back to 1884, when the German chemist Ludwig Knorr attempted to synthesize quinoline derivatives with antipyretic activity and accidentally obtained antipyrine, a pyrazolinone, ...
Efeito teratogênico do ditelureto de difenila, administrado durante a gestação em ratas e efeito de organocalcogênios sobre a reprodução em ratos machos
(Universidade Federal de Santa Maria, 2004-07-30)
Organochalcogens are important intermediates and the main applied reagents in organic synthesis and in industrial processes, which can increase human exposure risk to these chemicals in the workplace. The effects of single ...
Efeito do resveratrol nos sistemas colinérgico e purinérgico em encéfalo de ratos diabéticos
(Universidade Federal de Santa Maria, 2009-03-13)
Diabetes mellitus is a major public health problem throughout the world. Besides the most common complications in the peripheral nervous system, diabetes may also cause a series of cognitive, structural and functional ...
Efeito do exercício agudo de curta duração na atividade da enzima δ-aminolevulinato desidratase em humanos
(Universidade Federal de Santa Maria, 2009-02-27)
Aerobic exercise of sufficient intensity and duration can result in increased generation of reactive oxygen species and exercise of extreme endurance may cause oxidative stress with a concomitant decreased activity of ...
O complexo metilmercúrio-cisteína altera o acúmulo de mercúrio em diferentes tecidos de camundongo
(Universidade Federal de Santa Maria, 2009-03-26)
Methylmercury (MeHg) is related to several deleterious effects on the vertebrate tissues, mainly on central nervous system, and part of these effects are through of interaction with sulfhydryl group found in cellular ...
Toxicologia e farmacologia in vitro de novos compostos orgânicos de selênio e telúrio com atividade tipo tiol peroxidase
(Universidade Federal de Santa Maria, 2009-05-08)
Glutathione peroxidase (GPx; EC 1.11.1.9) is a well-known selenoenzyme that catalyzes the reduction of hydrogen peroxide and some organic hydroperoxides by glutathione (GSH) and protects lipid membranes and other cellular ...
Efeito neuroprotetor da creatina e avaliação dos parâmetros cinéticos da captação de glutamato induzidos pelo ácido glutárico no estriado de ratos
(Universidade Federal de Santa Maria, 2008-10-14)
Glutaric acidemia type I (GA-I) is an inborn error of metabolism (EIM) biochemically characterized by the main accumulation of glutaric acid (GA) and 3- hydroxyglutaric acid (3-OH-GA), and pathologically by a characteristic ...
Efeitos da Campomanesia xanthocarpa em parâmetros bioquímicos, hematológicos e de estresse oxidativo em pacientes hipercolestrolêmicos
(Universidade Federal de Santa Maria, 2009-11-16)
In Southern Brazil, the plant Campomanesia xanthocarpa Berg. (Myrtaceae), popularly known as guavirova , has been empirically used for its potential effect in reducing blood cholesterol levels. Since there are no scientific ...
Avaliação do potencial antinociceptivo e mecanismo de ação do 2-[5-triclorometil-5-hidroxi-3-fenil-4,5-dihidro-1hpirazol- 1-il] 4-(4 bromofenil)- 5 metiltiazol (b50) em camundongos
(Universidade Federal de Santa Maria, 2005-07-21)
Pain is a common symptom in the clinical practice. Therefore, novel analgesic drugs, with more favorable pharmacological properties have been searched. Previous studies from our group showed that the systemic administration ...