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Itens para a visualização no momento 21-30 of 49
Efeitos do glifosato sobre o desenvolvimento embrionário, larval e adulto do peixe-zebra (Danio rerio)
(Universidade Federal de Santa Maria, 2021-09-16)
Glyphosate-Based Herbicides (GBH) are the most used pesticides in the world and pose risks to environmental health and to non-target organisms. This work aimed to verify the toxicity, the mechanisms involved and the ...
Efeitos da curcumina sobre células neurais, diferenciação neural e sinalização purinérgica em embriões de camundongos com toxoplasmose
(Universidade Federal de Santa Maria, 2022-01-26)
Toxoplasmosis is a parasitic disease caused by the obligate intracellular protozoan Toxoplasma gondii. Its characteristics of encystment and persistence, preferably in the central nervous system of mammals, are worrying, ...
Avaliação dos efeitos do consumo de uma dieta rica em sacarose em Drosophila melanogaster: ênfase em alterações metabólicas e transcricionais
(Universidade Federal de Santa Maria, 2021-11-09)
The prevalence of diabetes mellitus (DM) has increased in the last decades, with 90% of cases been of type-2 diabetes (T2D), which is characterized by insulin resistance. In addition to hyperglycemia, T2D is strongly ...
Tratamento crônico com tamoxifeno de maneira dose-dependente afeta a memória e os fenótipos do tipo ansioso e depressivo em ratas Wistar intactas
(Universidade Federal de Santa Maria, 2022-07-28)
Tamoxifen, a selective estrogen receptor modulator, the gold standard for adjuvant therapy of breast cancer, has dichotomous effects on memory, anxious- and depressive-like phenotypes described in the literature. Studies ...
Estresse prolongado único-emocional induz distúrbio gastrointestinal funcional: um modelo de interação cérebro-intestino
(Universidade Federal de Santa Maria, 2022-08-30)
Currently, about 90% of the world’s population suffers from some degree of stress, making it an inevitability (WHO). It is known that excessive stress can precipitate psychopathologies, such as depression and anxiety, and ...
Efeitos in vitro e in vivo do bissulfato de clopidogrel em modelo experimental de melanoma: envolvimento do sistema purinérgico plaquetário
(Universidade Federal de Santa Maria, 2022-08-08)
Melanoma is a type of cancer that, when it develops into the metastatic form, is very aggressive and makes conventional antitumor treatments less effective. Activated platelets are involved in tumor progression through ...
O papel profilático do exercício físico sobre a modulação neurovascular e os efeitos da trombina no desenvolvimento de convulsões pós-traumáticas
(Universidade Federal de Santa Maria, 2021-08-30)
Traumatic brain injury (TBI) is considered a worldwide public health problem due to its high incidence and high public costs. Although the pathophysiology of TBI is multifaceted, the occurrence of coagulopathy is strongly ...
Efeitos do manganês sobre respostas neurocomportamentais e bioquímicas em peixe-zebra (Danio rerio)
(Universidade Federal de Santa Maria, 2022-03-25)
Manganese (Mn) is considered a important environmental pollutant, as well as a putative risk factor for neurodegenerative disorders. As the 12° most abundant element and comprising aproximattly 0,1% of the earth surface, ...
Efeitos do ácido clorogênico na modulação da sinalização purinérgica e perfil inflamatório em células microgliais expostas ao lipopolissacarídeo
(Universidade Federal de Santa Maria, 2021-09-16)
Neuroinflammation is a process associated with various neurodegenerative diseases, especially Parkinson’s and Alzheimer’s Disease. In the Central Nervous System (CNS), microglial cells are the most important macrophages ...
Papel do processo oxidativo/inflamatório na fisiopatologia induzida por concussões recorrentes em ratos jovens
(Universidade Federal de Santa Maria, 2022-08-05)
Concussion can be defined as a change in brain function caused by an external force. In recent years, it has received greater attention from the scientific community for its subtle effects, which can add up and worsen the ...