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Suscetibilidade in vitro e in vivo de Pythium insidiosum frente a antibacterianos (macrolídeos, oxazolidinonas e pleuromutilinas) e miltefosina
(Universidade Federal de Santa Maria, 2018-08-20)
Pythiosis is an infection caused by the oomycete Pythium insidiosum that affects humans and other wild and domestic mammals, presenting difficulties in both diagnosis and treatment. Pythiosis cases do not respond satisfactorily ...
Estudos químicos, moleculares, microbiológicos e toxicológicos de novas moléculas eficazes contra biofilmes de pseudomonas aeruginosa e micobactérias de crescimento rápido
(Universidade Federal de Santa Maria, 2021-07-12)
It is known that microbial infections caused by microorganisms in sessile form are a more challenging issue, with regard to pathogenesis and treatment, than infections caused by planktonic microorganisms. Biofilm maturation ...
Comparação de marcadores de estresse oxidativo em sangue, colostro e cordão umbilical após parto vaginal e cesáreo
(Universidade Federal de Santa Maria, 2021-08-20)
Pregnancy is characterized as an oxidative event with physiological changes in the
body to accommodate a developing fetus. The transition from pregnancy to the
postpartum period can occur through different types of births, ...
O extrato bruto das folhas da espécie Randia ferox (Cham & Schlecht) DC. apresenta adequado perfil de segurança e potencial antineuroinflamatório in vitro
(Universidade Federal de Santa Maria, 2021-08-27)
Neuropsychiatric diseases directly affect the quality of life of those affected and their families, becoming a public health problem. Among the hypotheses of its pathophysiology, neuroinflammation has been explored, making ...
Quantificação de biomarcadores em pacientes com fibromialgia submetidos a terapia com acupuntura
(Universidade Federal de Santa Maria, 2021-03-05)
Fibromyalgia (FM) is a syndrome characterized by chronic, diffuse pain and systemic
symptoms. Its etiology and pathogenesis are still not completely understood. The
therapy used in FM mainly consists of the use of ...
Efeitos da carbamilação in vitro sobre a quantificação da albumina pelos ensaios imunoturbidimétrico e colorimétrico
(Universidade Federal de Santa Maria, 2021-11-05)
Albumin is a low-molecular-weight non-glycosylated globular protein with several functions, such as maintaining colloidal osmotic pressure and transporting various substances. It is the main protein present in plasma. ...
Avaliação de potenciais biomarcadores séricos e salivares e do polimorfismo do gene da glutationa S-transferase P1 (GSTP1) na obesidade adulto jovem
(Universidade Federal de Santa Maria, 2015-11-20)
Obesity and overweight are complex clinical syndromes responsible for high morbidity and
mortality throughout the world, as they are risk factors for the development of Metabolic
Syndrome, diabetes mellitus, dyslipidemia, ...
Estudo de métodos físico-químicos e biológico para caracterização e avaliação do anticorpo monoclonal recombinante denosumabe
(Universidade Federal de Santa Maria, 2021-10-21)
Denosumab (DmAb) is monoclonal antibody (mAb) that inhibits proliferation and activity of osteoclasts cells, that is commercially available in Brazil as Prolia® and Xgeva®, for treatment of bone diseases. Structurally, it ...
Complexo Sporothrix schenckii: inativação fotodinâmica, influência da melanina na atividade dos antifúngicos e combinação de fármacos
(Universidade Federal de Santa Maria, 2015-02-12)
Sporotrichosis is a subcutaneous mycosis that affects humans and animals, and it is caused by dimorphic melanized fungi belonging to the genus Sporothrix. Sporotrichosis is mainly acquired by traumatic implantation of the ...
Investigação laboratorial da nefropatia diabética: avaliação de marcadores tubulares e do impacto da correção pela creatinina urinária
(Universidade Federal de Santa Maria, 2014-10-31)
Diabetic nephropathy (DN) is a multifactorial patholgy, characterized by the increased presence of albumin in urine. Currently, urinary albumin (uAlb) is a marker for glomerular damage mostly used for the diagnosis of DN; ...