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Atividade da NTPDase, 5 -nucleotidase, acetilcolinesterase e níveis de peroxidação lipídica em ratos expostos ao cádmio e tratados com curcumina
(Universidade Federal de Santa Maria, 2014-10-15)
Cadmium (Cd) is one of the most toxic metals in relation to environmental contamination and human poisoning. This metal has a long biological half-life (10-30 years) and prolonged exposure to Cd has been associated with ...
Ditelureto de difenila induz prejuízos no desenvolvimento, neurotoxicidade e desmielinização no sistema nervoso central de filhotes de ratos wistar
(Universidade Federal de Santa Maria, 2009-11-20)
The purpose of this study was to investigate if myelinogenesis is related to the mechanism by which diphenyl ditelluride [(PhTe)2] causes toxicity in rat pups. The present study was performed to examine whether the behavioral ...
Sensibilidade da enzima acetilcolinesterase (e.c. 3.1.1.7) à nicotina in vitro e in vivo
(Universidade Federal de Santa Maria, 2005-08-18)
This work valued the sensibility of the acetylcholinesterase from different sources and brain regions at nicotine in vitro, and the effects of the acute and subchronic exposures at the alkaloid on the brain acetylcholinesterase ...
Efeito do resveratrol nos sistemas colinérgico e purinérgico em encéfalo de ratos diabéticos
(Universidade Federal de Santa Maria, 2009-03-13)
Diabetes mellitus is a major public health problem throughout the world. Besides the most common complications in the peripheral nervous system, diabetes may also cause a series of cognitive, structural and functional ...
Estudo do sistema purinérgico e colinérgico no encéfalo de animais submetidos à hipoperfusão encefálica crônica e ao ambiente enriquecido
(Universidade Federal de Santa Maria, 2016-08-19)
Chronic cerebral hypoperfusion (CCH) has frequently been associated with neurodegenerative diseases. A persistent reduction of cerebral blood flow (CBF) changes the neuronal homeostasis causing diffuse ischemic damage and ...
Efeitos da VD3 sobre a memória e sobre o sistema purinérgico e colinérgico em um modelo de demência esporádica do tipo Alzheimer em ratos
(Universidade Federal de Santa Maria, 2014-06-13)
Alzheimer's disease (AD) is considered the main cause of dementia in elderly people worldwide. This disease affects the central nervous system (CNS), especially the cerebral cortex and hippocampus, areas that are responsible ...
Diazinon altera a atividade das colinesterases periféricas sem alterar o comportamento de camundongos
(Universidade Federal de Santa Maria, 2018-10-15)
Organophosphorus compounds (OP) belong to a class of chemical compounds which contain a pentavalent phosphorus atom in its structure, which is bound by a double bond to an oxygen atom or to a sulfur atom. They are commonly ...
Avaliação, in vitro, dos parâmetros cinéticos da enzima acetilcolinesterase cerebral de ratos frente a alguns compostos azóis
(Universidade Federal de Santa Maria, 2011-09-09)
The acetylcholinesterase enzyme is responsible for the acetylcholine
hydrolisis in the synaptic cleft during the transmission of nervous impulse. The
investigation of new inhibitors of this important enzyme is very ...
Avaliação do efeito inibitório do composto orgânico de selênio ebselen na atividade da enzima acetilcolinesterase cerebral de ratos in vitro
(Universidade Federal de Santa Maria, 2015-02-27)
Acetylcholinesterase (AChE) is an important regulatory enzyme that modulates cholinergic synapses by hydrolysis of acetylcholine (ACh), a neurotransmitter involved in many biological processes, especially in memory and ...
Avaliação da toxicidade do chumbo em parâmetros bioquímicos e comportamentais: efeito preventivo do zinco e N-acetilcisteína
(Universidade Federal de Santa Maria, 2017-01-30)
Lead (Pb) is a toxic metal without biological function, which can cause various undesirable changes in organism. Developing animals are more sensitive to external aggressions, and exposure to Pb may cause pronounced and ...