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Efeito antioxidante da creatina não protege da suscetibilidade à convulsões após traumatismo crânioencefálico em ratos
(Universidade Federal de Santa Maria, 2011-04-06)
Studies over recent years have highlighted the important role of creatine in health and in treating various neurological diseases. However, its role in secondary damage induced by traumatic brain injury (TBI) is not fully ...
Avaliação dos efeitos biológicos do (s) (3-feniltelanil propanamida) succinato de dimetila, um novo telúrio aminoácido derivado do ácido aspártico
(Universidade Federal de Santa Maria, 2011-03-25)
Recent studies from our group demonstrated that the (S)-dimethyl 2-(3-(phenyltellanyl) propanamido) succinate compound, a telluroamino acid showed glutathione peroxidase (GPx)-like activity, attesting to its antioxidant ...
Efeito de Paullinia cupana (Mart.) no estresse oxidativo induzido pelo nitroprussiato de sódio em celúlas de fibroblastos embrionários NIH-3T3
(Universidade Federal de Santa Maria, 2011-04-25)
The antioxidant effects of the hydro-alcoholic guaraná extracts (Paullinia cupana var. sorbilis
Mart.) on nitric oxide (NO ) and other compounds generated from degradation of Sodium
Nitroprusside (SNP) in embryonic ...
Avaliação, in vitro, dos parâmetros cinéticos da enzima acetilcolinesterase cerebral de ratos frente a alguns compostos azóis
(Universidade Federal de Santa Maria, 2011-09-09)
The acetylcholinesterase enzyme is responsible for the acetylcholine
hydrolisis in the synaptic cleft during the transmission of nervous impulse. The
investigation of new inhibitors of this important enzyme is very ...
Caracterização do esteróide α-espinasterol como um novo antagonista do receptor TRPV1 com efeito antinociceptivo
(Universidade Federal de Santa Maria, 2011-09-01)
The transient receptor potential vanilloid 1 (TRPV1) is relevant to the
perception of noxious information and has been studied as a therapeutic target for
the development of new analgesics. The goal of this study was to ...
Envolvimento do receptor TRPA1 na resposta inflamatória induzida pela administração tópica de cinamaldeído em camundongos
(Universidade Federal de Santa Maria, 2011-03-30)
Cinnamaldehyde, a natural compound frequently present in cosmetic formulations, induces skin irritation when topically applied, but the mechanism by which cinnamaldehyde produces such skin reactions is unclear. Here, we ...
Distribuição espaço-temporal de comunidades de girinos (Amphibia: Anura) no cerrado sul-mato-grossense
(Universidade Federal de Santa Maria, 2011-02-25)
We studied species richness, abundance and spatial-temporal distribution of tadpole
communities in eight ponds in an area of Cerrado in the state of Mato Grosso do Sul, Brazil.
We carried out this study during a rainy ...
Espermidina diminui a atividade da enzima Na+,K+-ATPase pela via de sinalização NMDA/NOS/GMPc/PKG em hipocampo de ratos
(Universidade Federal de Santa Maria, 2011-12-02)
Spermidine (SPD) is an endogenous polyamine with polycationic structure present in the central nervous system of mammals. SPD regulates biological processes, such as Ca2+ influx by glutamatergic N-methyl-D-aspartate receptor ...
Perfil farmacológico do tipo antidepressivo do composto 3-(4-fluorofenilselenil)-2,5 difenilselenofeno: envolvimento do sistema serotoninérgico
(Universidade Federal de Santa Maria, 2011-02-23)
Depression is a serious, recurrent and incapacitating psychiatric condition with a
heavy social burden. The pharmacological approach to this disorder employs therapy with
antidepressant drugs, which have side effects and ...
Efeitos do exercício físico sobre parâmetros de estresse oxidativo em ratos hipertensos
(Universidade Federal de Santa Maria, 2011-09-05)
Hypertension has been regarded as one of the most important factors associated with the
development of vascular disease and is closely linked to increased reactive oxygen species (ROS). In
contrast, exercise has been ...