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Avaliação das toxicidades do suco do fruto de Plinia cauliflora em ratos Wistar
(Universidade Federal de Santa Maria, 2020-12-07)
Plants have always been an essential item for human life, being used as raw material, food, and medicine alike. Even today, with all the developments in medicine, plants are still a fundamental source of solutions. Given ...
Compostos voláteis como sedativos, anestésicos e antinociceptivos em peixes
(Universidade Federal de Santa Maria, 2020-02-18)
Natural products are a drug discovery source for both humans and veterinary treatment. Consequently, in the last decade, essential oils have been researched as fish anesthetics and sedatives, however, there are a small ...
Avaliação da exposição in vivo ao formaldeído sobre parâmetros do estresse oxidativo, inflamação e modificações epigenéticas
(Universidade Federal de Santa Maria, 2020-10-23)
Air quality has been discussed for some time among the scientific community. Air pollution in the external environment and that of the indoor environment have been caused for concern. Volatile organic compounds (VOCs) are ...
Participação do receptor TRPA1 na nocicepção observada em um modelo de esclerose múltipla progressiva em camundongos
(Universidade Federal de Santa Maria, 2020-03-25)
Central neuropathic pain (CNP) is a common untreated symptom in progressive multiple sclerosis (PMS) and is associated with poor quality of life and interference with patients’ daily activities. The neuroinflammation process ...
Avaliação do papel do receptor para tromboxanos (TP) durante a epileptogênese
(Universidade Federal de Santa Maria, 2020-03-05)
Convulsive status epilepticus (SE) is a medical emergency that can lead to epilepsy, long lasting brain damage and death. It is known that there is a strong link between epilepsy and inflammation. For instance, it has been ...
Envolvimento de fatores oxidativos e inflamatórios sobre a resistência ao tratamento com fluoxetina em um modelo de depressão em camundongos
(Universidade Federal de Santa Maria, 2021-10-27)
Major depression (DM) is among the most disabling mental disorders in the world. According to the World Health Organization (WHO), more than 300 million people are affected by DM. The disorder is characterized by a set of ...
Efeito do beta-cariofileno na suscetibilidade hepática e renal à aflatoxina B1 em parâmetros bioquímicos, oxidativos e moleculares em ratos
(Universidade Federal de Santa Maria, 2021-08-13)
Aflatoxin B1 (AFB1) is a mycotoxin produced manly by Aspergillus flavus and Aspergillus
parasiticus fungi. Among the existing mycotoxins, AFB1 has been the most studied due to its
high toxigenic potential. Exposure to ...
Depressão: aspectos fisiopatológicos e o efeito tipo-antidepressivo da apocinina
(Universidade Federal de Santa Maria, 2020-02-17)
Depression is considered a public health challenge around the world. According to the World Health Organization, more than 300 million people (approximately 6% of the world population) are affected by this disorder. ...
Envolvimento do canal TRPA1 nos comportamentos do tipo depressivo e ansioso em um modelo de esclerose múltipla progressiva em camundongos
(Universidade Federal de Santa Maria, 2020-09-25)
Background and Purpose: Progressive multiple sclerosis (PMS) is a neurological disease associated with the development of depression and anxiety, and treatments available are unsatisfactory. The transient potential receptor ...
Efeito modulatório in vitro da quetiapina não-metabolizada na citotoxicidade e ativação inflamatória de células brancas e na formação de armadilhas extracelulares de neutrófilos
(Universidade Federal de Santa Maria, 2020-02-19)
Quetiapine (QUE) is a highly complex drug that, due to its different forms of interaction with receptors, has great clinical applicability. Although widely used, QUE brings with it a range of side effects that include, in ...