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Envolvimento de fatores oxidativos e inflamatórios sobre a resistência ao tratamento com fluoxetina em um modelo de depressão em camundongos
(Universidade Federal de Santa Maria, 2021-10-27)
Major depression (DM) is among the most disabling mental disorders in the world. According to the World Health Organization (WHO), more than 300 million people are affected by DM. The disorder is characterized by a set of ...
Efeito do beta-cariofileno na suscetibilidade hepática e renal à aflatoxina B1 em parâmetros bioquímicos, oxidativos e moleculares em ratos
(Universidade Federal de Santa Maria, 2021-08-13)
Aflatoxin B1 (AFB1) is a mycotoxin produced manly by Aspergillus flavus and Aspergillus
parasiticus fungi. Among the existing mycotoxins, AFB1 has been the most studied due to its
high toxigenic potential. Exposure to ...
Beta-cariofileno atenua dano cognitivo induzido pela exposição ao aspartame em ratos pela modulação da atividade da acetilcolinesterase e da Via BDNF/TrKB
(Universidade Federal de Santa Maria, 2021-08-26)
Aspartame (ASP) is a widely used as a tabletop sweetener and sucrose substitute in many
food matrices. However, several studies have reported that exposure to ASP can damage
biological tissues, such as the central nervous ...
Efeitos benéficos do ácido rosmarínico em modelos de atividade epileptiforme in vivo e in vitro induzidos por pilocarpina
(Universidade Federal de Santa Maria, 2021-12-17)
Epilepsy is a chronic neurological condition marked by the occurrence of epileptic seizures that cause enormous damage to the quality of life of affected patients. Thus, understanding the molecular bases responsible for ...
Associação entre β-cariofileno e pregabalina apresenta ação anticonvulsivante aguda em modelo de crises epilépticas induzidas por pentilenotetrazol em ratos
(Universidade Federal de Santa Maria, 2021-07-23)
Epilepsy is a chronic neurological disease characterized by recurrent seizures. However, current anticonvulsants are ineffective in nearly a third of patients and can cause adverse effects. Beta-caryophyllene is agonist ...