Buscar
Itens para a visualização no momento 1-10 of 12
Efeitos protetores do zinco sobre alterações comportamentais e bioquímicas induzidas pelo mercúrio em ratos jovens
(Universidade Federal de Santa Maria, 2009-12-21)
Mercury is a toxic element that induces biochemical, neurological and behavioral changes, which can persist for a long time after the metal exposure. The contamination by mercury continues being a serious problem of public ...
Avaliação do sistema purinérgico e colinérgico em córtex de ratos após hipóxia-isquemia neonatal
(Universidade Federal de Santa Maria, 2013-03-15)
Hypoxia-ischemia (HI) neonatal is a major cause of morbidity and mortality during the perinatal period and it is an important risk factor for the development of a number of human neurological disorders, such as cerebral ...
Os efeitos do ácido cafeico e do éster fenetil do ácido cafeico sobre as atividades da acetilcolinesterase e das ecto-nucleotidases em ratos
(Universidade Federal de Santa Maria, 2013-01-21)
Phenolic compouds and their derivatives constitute a leading family of natural compounds. Caffeic acid (CA) and
caffeic acid phenethyl ester (CAPE) are the important members of phenolic compound, sharing several ...
Avaliação do potencial antinociceptivo da Mirabilis jalapa L. em camundongos
(Universidade Federal de Santa Maria, 2010-12-09)
The knowledge about the use of medicinal plants by the population contributed decisively to the modern therapy and the discovery of important mechanisms related to the process of transmission and treatment of pain. A plant ...
Avaliação de novos compostos sobre a atividade de colinesterases em modelos in silico e in vitro
(Universidade Federal de Santa Maria, 2012-06-04)
The enzyme acetylcholinesterase (EC 3.1.1.7, AChE) is responsible to terminate acetylcholine activity in
the terminal nervous junctions with its effector organs or post-synaptic sites. The activity of this enzyme
could ...
Benznidazol livre e nanoestruturado na terapia da Doença de Chagas experimental e seus efeitos sobre biomarcadores do sistema colinérgico e estresse oxidativo
(Universidade Federal de Santa Maria, 2022-01-27)
Chagas disease (CD) is widely distributed in Latin America, caused by Trypanosoma cruzi. The infection promotes an inflammatory process, which triggers several factors of the immune response. The cholinergic system acts ...
Avaliações neuroquímicas, enzimáticas e comportamentais em ratos infectados experimentalmente com trypanosoma evansi e utilização da curcumina como possível agente terapêutico
(Universidade Federal de Santa Maria, 2013-05-20)
The pathogenesis of Trypanosoma evansi (T. evansi) infection on central and peripheral nervous
system (CNS) and immunologic system it is not completely understood. This study was conducted to
investigate the effects of ...
Papel potencial do ácido rosmarínico sobre biomarcadores de estresse oxidativo e acetilcolinesterase de ratos diabéticos induzidos por estreptozotocina
(Universidade Federal de Santa Maria, 2013-04-22)
Oxidative stress plays an important role in diabetic pathogenesis. Rosmarinic acid
(RA) was used for the first time as an antioxidant agent for inhibition of diabetic
nephropathy. Oxidative stress induced by Streptozotocin ...
Potenciais efeitos da cafeína sobre parâmetros bioquímicos e inflamatórios em ratos submetidos ao treinamento intervalado de alta intensidade
(Universidade Federal de Santa Maria, 2017-01-31)
Caffeine has been used as ergogenic substance for the purpose of improving athletic performance or attenuating fatigue mechanisms. However, the ergogenic effect of caffeine on high-intensity exercise remains controversial ...
Caracterização da atividade da enzima acetilcolinesterase de veneno de bungarus sindanus: estudos comparativos
(Universidade Federal de Santa Maria, 2008-03-10)
Acetylcholinesterase (AChE) belongs to a distinct family of serine hydrolases and is found in both synaptic and non-synaptic locations. At the synapses, it plays a major role
in the hydrolysis of the neurotransmitter ...