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Estudo de mecanismos de toxicidade do metilmercúrio: papel protetor de flavonóides
(Universidade Federal de Santa Maria, 2010-08-12)
Methylmercury (MeHg) is an important environmental toxicant that may cause irreversible neurobehavioral and neuropsychological disorders in humans and experimental animals. The major mechanisms of MeHg-induced toxicity ...
Efeito in vitro do extrato de Solanum sessiliflorum: atividade antioxidante e antitumoral (MCF-7 e HT29)
(Universidade Federal de Santa Maria, 2015-11-05)
Epidemiological studies have suggested that intake of fruits and vegetables act in the prevention of several diseases such as cancer and cardiovascular diseases. This can be explained by these bioactive compounds are present ...
Avaliação do potencial antioxidante e antibacteriano de Anacardium microcarpum e sua toxicidade em diferentes modelos biológicos in vitro
(Universidade Federal de Santa Maria, 2015-09-11)
Oxidative stress reflects an imbalance between the systemic manifestation of reactive species and a biological system s ability to readily detoxify the reactive intermediates or to repair the resulting damage. This condition ...
Consumo de mel fornece proteção contra alterações motoras e moleculares induzidas por hipóxia/reperfusão em Drosophila melanogaster
(Universidade Federal de Santa Maria, 2017-02-14)
Honey is a complex product produced by honeybees from nectar, being widely used for its sweetening properties, as well as for its benefits to human health. Honey presents anti-inflammatory, hypoglycemic and antioxidant ...
Propriedades antinociceptivas e antioxidantes do disseleneto de bis(fenilimidazoselenazolila) em roedores
(Universidade Federal de Santa Maria, 2016-11-07)
The current available drugs for treatment of disorders related to pain and inflammation present several adverse effects, then the investigation for novel molecules are required. It is known that organoselenium compounds ...
JM-20 como composto multialvo: avaliação do potencial antioxidante, inibidor de colinesterases e citotoxicidade
(Universidade Federal de Santa Maria, 2020-10-29)
Multi-target compounds have aroused the interest of many researchers. The main characteristic of these substances is the ability to act through different mechanisms of action, a relevant fact in cases of pathologies caused ...
Neuroproteção do cassis (Ribes nigrum L.) e de sua associação com o Donepezil em modelo de amnésia induzida por escopolamina
(Universidade Federal de Santa Maria, 2019-12-13)
Memory deficits that occur with the process of aging could also be associated with the pathophysiology of neurodegenerative diseases, such as Alzheimer’s disease (AD). AD is characterized by the progressive deterioration ...
Síntese e atividades antioxidante e antitumoral de 5´-arilseleno azidotimidina
(Universidade Federal de Santa Maria, 2012-03-30)
The synthesis of compounds that use a nucleoside as the base structure, has an intense field application. Among these compounds, the most known nowadays is azydothymidine or zidovudine, a drug which was first synthesized ...
Avaliação de marcadores bioquímicos, de estresse oxidativo e do efeito antioxidante da quercetina no hipotireoidismo
(Universidade Federal de Santa Maria, 2014-03-28)
Hypothyroidism is characterized by a disorder resulting from deficiency of
thyroid hormones and is related to lipid metabolism dysfunction and cardiovascular
diseases development risk. However, these changes in hypothyroidism ...
Parâmetros toxicológicos em piavas (Leporinus obtusidens) e jundiás (Rhamdia quelen) após exposição a uma formulação comercial de glyphosate
(Universidade Federal de Santa Maria, 2008-02-15)
The commercial formulations of glyphosate herbicide have been widely used in agriculture and pisciculture for controlling plant weeds. Fish can be affected when drainage water reaches water courses, causing a disturbance ...