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Efeito do Harpagophytum procumbens sobre parâmetros de estresse oxidativo e a viabilidade celular in vitro
(Universidade Federal de Santa Maria, 2013-10-04)
Harpagophytum procumbens, known as devil's claw, is an African plant with numerous therapeutic effects, among which stands out for its powerful anti-inflammatory action, but the mechanism by which exerts its effect is not ...
Efeitos do disseleneto de difenila sobre o dano oxidativo causado por paracetamol em cérebro de camundongos
(Universidade Federal de Santa Maria, 2012-06-11)
Acetaminophen (APAP) is the analgesic most used in world, in therapeutic doses does not show toxicity, but in elevated doses can cause hepatic damage due the formation of his metabolic toxic N-acetyl-p-benzoquinonimine ...
Caracterização físico-química do mel do bioma pampa brasileiro e estudo do seu potencial antioxidante in vitro e in vivo em modelo de Drosophila melanogaster
(Universidade Federal de Santa Maria, 2014-03-14)
Honey is a complex mixture produced by honey bees from the nectar, which is used by
its sweetening properties, as well as by its human health benefits. The aim of this study was to
characterize, for the first time in ...
Centella asiática reduz peroxidação lipídica induzida por ácido quinolínico e nitroprussiato de sódio in vitro em regiões do cérebro de rato
(Universidade Federal de Santa Maria, 2014-08-21)
The oxidative stress is envolved in several diseases, including neurological diseases. Centella asiatica is a medicinal plant which was has long been used to treat neurological disturbances in Ayurvedic medicine. The aim ...
Avaliação dos efeitos de drogas anti-adenosinérgicas e do disseleneto de difenila no prejuízo da memória e estresse oxidativo relacionados ao envelhecimento
(Universidade Federal de Santa Maria, 2012-08-08)
Biological aging is gradual and progressive decline of physical functions that begin in adulthood and ends with death in almost all animals species. One of the most common features of aging is the reduced ability to learn ...
Efeitos do tratamento com ácido gálico sobre parâmetros oxidativos, moleculares e comportamentais induzidos por cetamina em ratos
(Universidade Federal de Santa Maria, 2019-12-20)
Ketamine is a dissociative anesthetic drug, which blocks NMDA glutamatergic receptors for restricted clinical use due to its high addictive potential. Studies have shown neurotoxicity and memory impairments development ...
Depressão: aspectos fisiopatológicos e o efeito tipo-antidepressivo da apocinina
(Universidade Federal de Santa Maria, 2020-02-17)
Depression is considered a public health challenge around the world. According to the World Health Organization, more than 300 million people (approximately 6% of the world population) are affected by this disorder. ...
Efeitos benéficos do ácido rosmarínico em modelos de atividade epileptiforme in vivo e in vitro induzidos por pilocarpina
(Universidade Federal de Santa Maria, 2021-12-17)
Epilepsy is a chronic neurological condition marked by the occurrence of epileptic seizures that cause enormous damage to the quality of life of affected patients. Thus, understanding the molecular bases responsible for ...
Oximas como inibidores da oxidação de lipoproteínas de baixa densidade
(Universidade Federal de Santa Maria, 2009-06-09)
The oxidation of low density lipoprotein is now an established hypothesis of atherogenesis and suggests that accumulation of oxidized low density lipoprotein (oxLDL) in the vessel wall is an early event in disease progression. ...
Richardia brasiliensis Gomes: composição fitoquímica, atividade biológica e toxicidade
(Universidade Federal de Santa Maria, 2022-07-22)
Medicinal plants are used both in chemoprevention and in the treatment of a disease after it has already
been installed. In general, despite the wide use, knowledge about the phytochemical composition,
biological activities, ...