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Itens para a visualização no momento 11-20 of 34
Propriedades antinociceptivas e antioxidantes do disseleneto de bis(fenilimidazoselenazolila) em roedores
(Universidade Federal de Santa Maria, 2016-11-07)
The current available drugs for treatment of disorders related to pain and inflammation present several adverse effects, then the investigation for novel molecules are required. It is known that organoselenium compounds ...
Ação neuroprotetora e anti-inflamatória do disseleneto de difenila e exercício de natação em modelo de envelhecimento em ratos
(Universidade Federal de Santa Maria, 2016-01-29)
Aging is a degenerative process that affects virtually all living organisms. The increase in the inflammatory process seems to be one of the main factors that contribute to aging and inflammaging and neuroinflammation in ...
Alterações sexo-específicas na memória e homeostase glutamatérgica induzidas por bisfenol A em camundongos: efeito do disseleneto de difenila
(Universidade Federal de Santa Maria, 2017-03-03)
Bisphenol A (BFA) is an endocrine disruptor with high toxicological potential, used in the manufacture of
synthetic polymers, including food and beverage packaging. Even though the deleterious effects of BPA
exposure ...
Ação farmacológica do 4,4’-dicloro-difenil disseleneto em modelos de hiperglicemia e obesidade em ratos
(Universidade Federal de Santa Maria, 2017-03-03)
The obesity epidemic is a worldwide public health problem and is considered one of the leading causes of death and disability worldwide. This is because the pathophysiology of this disease is extremely complex and involves ...
Desenvolvimento de nanocápsulas contendo disseleneto de bis (p-metoxifenila): biodistribuição e efeitos em modelos de dor em camundongos
(Universidade Federal de Santa Maria, 2017-08-11)
The chronic pain is a global public health problem and its pharmacological management is still unsatisfactory. The identification of novel molecules to effectively treat chronic pain states remains a major objective in ...
Estudo comparativo de β-selenoaminas e disselenetos em modelos hepatotóxico e alternativo
(Universidade Federal de Santa Maria, 2017-08-17)
Organic selenium compounds, Ebselen and diphenyl diselenide (DPDS), possess numerous characteristics such as, antioxidant activity, anti-inflammatory among others. In this regard, new molecules have been produced through ...
Síntese e atividades antioxidante e antitumoral de 5´-arilseleno azidotimidina
(Universidade Federal de Santa Maria, 2012-03-30)
The synthesis of compounds that use a nucleoside as the base structure, has an intense field application. Among these compounds, the most known nowadays is azydothymidine or zidovudine, a drug which was first synthesized ...
Envolvimento do sistema dopaminérgico na ação do tipo antidepressiva do fenilselenometil em camundongos fêmeas
(Universidade Federal de Santa Maria, 2013-08-05)
Depression affects millions of people of different ages, races, religions and income at some period of their lives. The etiology of most mood disorders, although not fully understood, has come into sharper focus in the ...
Envolvimento dos sistemas adenosinérgico e dopaminérgico no efeito antinociceptivo de um derivado do selenoesterol em modelos de nocicepção aguda em camundongos
(Universidade Federal de Santa Maria, 2014-08-01)
Pain is a complex, multifactorial and protective process essential to the preservation of the integrity of the organisms, but when it becomes persistent its presence is devastating, which considerably reduces the well-being ...
Avaliação dos efeitos farmacológico e toxicológico de 4- organocalcogeno-isoquinolinas
(Universidade Federal de Santa Maria, 2014-03-12)
Monoamine oxidase (MAO) is a target enzyme in the treatment of several
pathologies, being that new molecules which inhibit of a selective, potent and
reversible manner their isoforms and without adverse effects are ...