Polimorfismo do gene SPi2 na obstrução recorrente das vias aéreas e na doença inflamatória das vias aéreas em cavalos puro sangue de corrida

Abstract

Recurrent airway obstruction (RAO) and inflammatory airway disease (IAD) show high prevalence and are economically important in equine athletes. RAO is considered a multifactorial disease due to genetic and environmental components in their patophysiology. The aim of this study was to determine the presence of polymorphism at exons 2, 3, 4 and 5 of the SPi2 gene and a possible association between them and ORA or IAD on 51 thoroughbred horses through single-strand conformational polymorphism (SSCP). Exons 2, 3 and 4 of the Spi2 gene showed no polymorphism. On exon 5, 3 alleles and 6 genotypes were identified. Frequency of allele A (0.6388) and genotype AA (0.3888) were higher in horses affected by RAO but no association was found between any polymorphism and horses with RAO or IAD.