Hirsutismo autorreportado e comorbidades na pós-menopausa

Abstract

Polycystic Ovarian Syndrome (PCOS) is the most frequent metabolic disorder in the female population. It affects 10% of women of childbearing age, and its pathophysiology, although not completely known, is associated with insulin resistance, hyperandrogenism and gonadotropin alteration. The diagnosis is of exclusion and is difficult due to the multiple phenotypes found, being fundamental the presence of menstrual dysfunction and alteration of the levels of androgens. Hirsutism, increased pilification in androgen-dependent areas, is a frequent complaint and correlates with PCOS in up to 95% of cases. Women with PCOS are at greater risk for developing metabolic syndrome and cardiovascular disease. These comorbidities usually manifest with aging and there are no guidelines for diagnosing PCOS after menopause. Because of this, we have attempted to prove the hypothesis that the history of self-reported hirsutism and / or oligomenorrhea influences the calculation of risk for comorbidities after menopause (type 2 diabetes mellitus, asthma, chronic bronchitis or emphysema, osteoarthritis, stroke, Heart failure, angina or myocardial infarction, multiple sclerosis, neoplasia, and Parkinson's disease). This cross-sectional study investigated women (1057) with at least 55 years of age, post-menopausal, with no cognitive deficit and / or communication difficulty who were seen in primary care services in a municipality in the south of Brazil during the 24-month period, Through a structured questionnaire that collected self-reported data on the presence of comorbidities, reproductive history and complaint of hirsutism in menacme. A significantly higher prevalence of comorbidities was found in women with a history of hirsutism and / or oligomenorrhea [OR = 1.6 (95% CI 1.1-2.4), or = hirsutism [OR 2.0 95% CI 1.3-3.2), P = 0.004]. As well as the prevalence of stroke, angina or myocardial infarction, heart failure, chronic obstructive pulmonary disease and osteoarthritis were significantly higher (p <0.03). Therefore, the presence of hirsutism and oligomenorrhea in menacing are risk factors for comorbidities, mainly cardiovascular, these alterations are possibly associated with the presence of PCOS, so its correct diagnosis in the menacme could avoid the reduction of quality of life in senectude.