Síntese, análise estrutural e avaliação da atividade inibitória da enzima urease por oxidovanádio (IV) e dioxidovanádio (V) complexos derivados de hidrazidas aromáticas

Abstract

This work presents the synthesis and characterization of vanadium complexes and the potential of these compounds to inhibit the enzyme urease. The complexes were obtained from the aldol condensation between substituted aromatic hydrazides and aldehydes (salicylic aldehyde and pyridoxal hydrochloride), resulting in six vanadium complexes. The complexes were characterized structurally by X-ray diffraction, ultraviolet spectrometry and in the visible and infrared region. Subsequently the compounds will be evaluated for their inhibitory activity against the enzyme urease.