Compostos de coordenação contendo o ligante 3-amino-2-((piridin-2-ilmetil)selanil)piridina: análise estrutural e atividade antibacteriana

Abstract

This work describes the synthesis, structural characterization, and antibacterial evaluation of eight new coordination compounds (1-8), derived from CuI, CuII, CoII, and ZnII, with 3-amine-2-((pyridin-2-ylmethyl)selanyl)pyridine (L) as ligand. Five complexes (1-3, 6 and 7) were obtained by slow diffusion from overlayed solutions of L and different metallic salts, and three (4, 5 and 8) by conventional one-pot reactions under reflux. Six products (1-3, 5-7) were characterized by single-crystal X-ray diffraction and four (3, 5-7) by X-ray powder diffraction. Two ZnII complexes (6 and 8) were characterized by 1D (1H, 13C and 77Se) and 2D (COSY, HMQC/HSQC) NMR spectroscopy. Five compounds were evaluated by elementary analysis (1-4 and 6), and all of them were characterized by FT-IR and UV-Vis spectroscopies. The eight compounds and their respective starting materials were tested against Staphylococcus aureus and Escherichia coli bacterias, to evaluate their potential antibacterial action through their MIC (minimum inhibitory concentration) and MBC (minimum bactericidal concentration) results. The compounds have shown different yet interesting behaviors, and five out of the eight complexes presented antibacterial activity. Such results prove the interest in studying this class of compounds in order to contribute to the synthesis of new antibacterial metal complexes.