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Atividade da NTPDase, 5 -nucleotidase, acetilcolinesterase e níveis de peroxidação lipídica em ratos expostos ao cádmio e tratados com curcumina
(Universidade Federal de Santa Maria, 2014-10-15)
Cadmium (Cd) is one of the most toxic metals in relation to environmental contamination and human poisoning. This metal has a long biological half-life (10-30 years) and prolonged exposure to Cd has been associated with ...
Estudo do sistema purinérgico e colinérgico no encéfalo de animais submetidos à hipoperfusão encefálica crônica e ao ambiente enriquecido
(Universidade Federal de Santa Maria, 2016-08-19)
Chronic cerebral hypoperfusion (CCH) has frequently been associated with neurodegenerative diseases. A persistent reduction of cerebral blood flow (CBF) changes the neuronal homeostasis causing diffuse ischemic damage and ...
Efeitos da VD3 sobre a memória e sobre o sistema purinérgico e colinérgico em um modelo de demência esporádica do tipo Alzheimer em ratos
(Universidade Federal de Santa Maria, 2014-06-13)
Alzheimer's disease (AD) is considered the main cause of dementia in elderly people worldwide. This disease affects the central nervous system (CNS), especially the cerebral cortex and hippocampus, areas that are responsible ...
Diazinon altera a atividade das colinesterases periféricas sem alterar o comportamento de camundongos
(Universidade Federal de Santa Maria, 2018-10-15)
Organophosphorus compounds (OP) belong to a class of chemical compounds which contain a pentavalent phosphorus atom in its structure, which is bound by a double bond to an oxygen atom or to a sulfur atom. They are commonly ...
Efeito da hesperidina sobre o déficit cognitivo e o sistema colinérgico de ratos submetidos a um modelo de demência esporádica do tipo alzheimer
(Universidade Federal de Santa Maria, 2017-10-16)
Alzheimer's disease (AD) is considered the main cause of dementia in the world and the search for new therapeutic interventions for its treatment is of great relevance. Preclinical studies suggest the use of hesperidin ...
Avaliação, in vitro, dos parâmetros cinéticos da enzima acetilcolinesterase cerebral de ratos frente a alguns compostos azóis
(Universidade Federal de Santa Maria, 2011-09-09)
The acetylcholinesterase enzyme is responsible for the acetylcholine
hydrolisis in the synaptic cleft during the transmission of nervous impulse. The
investigation of new inhibitors of this important enzyme is very ...
Avaliação do efeito inibitório do composto orgânico de selênio ebselen na atividade da enzima acetilcolinesterase cerebral de ratos in vitro
(Universidade Federal de Santa Maria, 2015-02-27)
Acetylcholinesterase (AChE) is an important regulatory enzyme that modulates cholinergic synapses by hydrolysis of acetylcholine (ACh), a neurotransmitter involved in many biological processes, especially in memory and ...
Avaliação da toxicidade do chumbo em parâmetros bioquímicos e comportamentais: efeito preventivo do zinco e N-acetilcisteína
(Universidade Federal de Santa Maria, 2017-01-30)
Lead (Pb) is a toxic metal without biological function, which can cause various undesirable changes in organism. Developing animals are more sensitive to external aggressions, and exposure to Pb may cause pronounced and ...
Efeito da curcumina sob a atividade das enzimas ntpdase e acetilcolinesterase em linfócitos de ratos expostos à fumaça do cigarro
(Universidade Federal de Santa Maria, 2010-08-19)
The exposure to the cigarette smoke xenobiotics is related with a compromised immune system and the development of many diseases such as Chronic Obstructive Pulmonary Disease (COPD) and lung cancer. The NTPDase ...
Efeito da quercetina na atividade de ectoenzimas e da acetilcolinesterase em sinaptossomas do córtex cerebral de ratos expostos ao cádmio
(Universidade Federal de Santa Maria, 2012-02-27)
Cadmium (Cd) is one of the most toxic heavy metals by their ability to affect the vital
organs like liver, kidney, brain and other. This metal can trigger a framework of
oxidative stress by increase of reactive oxygen ...