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Contribuição do receptor vaniloide na nocicepção induzida pela injeção periférica de poliaminas em camundongos
(Universidade Federal de Santa Maria, 2010-12-02)
Polyamines (putrescine, spermidine and spermine) are important endogenous regulators of ion channels, such as vanilloid (TRPV1), glutamatergic (NMDA or AMPA/kainate) and acid-sensitive (ASIC) receptors. In the present ...
Efeitos da N-acetilcisteína sobre o dano oxidativo renal e hepático de ratos diabéticos
(Universidade Federal de Santa Maria, 2010-10-22)
Diabetes mellitus (DM) is a chronic disease characterized by hyperglycemia, which is related to oxidative stress and plays an important role in the development of other diseases and tissue damage, such as liver and kidney ...
Caracterização, avaliação antioxidante e citotóxica dos extratos da polpa e da casca de tucumã (Astrocaryum aculeatum)
(Universidade Federal de Santa Maria, 2012-09-24)
The identification of bioactive compounds in Brazilian fruit is extremely important for bioprospecting of natural substances with potential pharmacotherapeutic. Likewise, evaluations of profiles of antioxidant activity and ...
Estudo da relação entre os níveis de indicadores biológicos de exposição ao tolueno e o estresse oxidativo em expostos ocupacionalmente a tintas
(Universidade Federal de Santa Maria, 2010-03-19)
Paints occupational exposure is an important health problem due to the wide variety of chemicals and xenobiotics present in their constitution. Organic solvents and heavy metals
are among the main chemical constituents ...
Suscetibilidade in vitro de Malassezia pachydermatis frente a agentes antifúngicos e frações de óleos essenciais
(Universidade Federal de Santa Maria, 2014-03-14)
The yeast Malassezia pachydermatis belongs to the normal microbiota of animals, and is usually implicated as responsible for otitis media and recently by various forms of dermatitis, mainly in dogs. This study aimed to ...
Efeito do Triterpeno 3β, 6β, 16β , trihidroxilup-20(29)-eno nas convul-sões induzidas por pentilenotretazol: papel da Na+, K+ ATPase
(Universidade Federal de Santa Maria, 2013-09-30)
Epilepsy is a syndrome characterized by spontaneous recurrent seizures, result of paroxys-mal discharges , excessive or synchronous a neural population . Despite the good prognosis, the high number of patients with epilepsy ...
Espermina reverte o dano de memória induzido por lipopolissacarídeo em camundongos
(Universidade Federal de Santa Maria, 2014-08-21)
Neuroinflammation is a neuropathological finding in a number of neurodegenerative diseases. Intraperitoneal injection of lipopolysaccharide (LPS) induces neuroinflammation and memory deficit. Spermine and spermidine are ...
A influência do desbalanço superóxido- peróxido de hidrogênio na resposta à quimioterapia de células de câncer colorretal (HT-29): estudo in vitro
(Universidade Federal de Santa Maria, 2016-02-16)
Introduction: manganese dependent superoxide dismutase (SOD2), is an important antioxidant
enzyme, superoxide dismutase to anion produced in mitochondria in hydrogen peroxide, which in turn
is catalyzed by glutathione ...
Creatina aumenta a atividade da Na+,K+-ATPase e previne o aparecimento das convulsões induzidas por pentilenotetrazol em ratos
(Universidade Federal de Santa Maria, 2010-02-26)
Creatine, an endogenous guanidino compound produced on liver, kidneys, pancreas, testes and brain, has been aim of several studies over the last years. Although most studies attribute the effects of creatine to their
energetic ...
Susceptibilidade de isolados de Malassezia pachydermatis sensíveis e resistentes ao fluconazol frente a antifúngicos e óleos essenciais.
(Universidade Federal de Santa Maria, 2011-02-01)
Malassezia pachydermatis is an opportunistic fungus associated to dermatomycoses and
otopathies in domestic and wild animals. The aim of this study was to compare the
susceptibility profile of clinical isolates of M. ...