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Avaliação da atividade de três compostos do óleo de melaleuca sobre o Trypanosoma evansi
(Universidade Federal de Santa Maria, 2016-02-15)
This study aimed the evaluation of the trypanocidal activity of terpinen-4-ol, γ-terpinene and α-terpinene against Trypanosoma evansi in vivo and in vitro. The in vitro assay was performed in culture medium of T. evansi, ...
Avaliação das toxicidades do suco do fruto de Plinia cauliflora em ratos Wistar
(Universidade Federal de Santa Maria, 2020-12-07)
Plants have always been an essential item for human life, being used as raw material, food, and medicine alike. Even today, with all the developments in medicine, plants are still a fundamental source of solutions. Given ...
Compostos voláteis como sedativos, anestésicos e antinociceptivos em peixes
(Universidade Federal de Santa Maria, 2020-02-18)
Natural products are a drug discovery source for both humans and veterinary treatment. Consequently, in the last decade, essential oils have been researched as fish anesthetics and sedatives, however, there are a small ...
Avaliação da exposição in vivo ao formaldeído sobre parâmetros do estresse oxidativo, inflamação e modificações epigenéticas
(Universidade Federal de Santa Maria, 2020-10-23)
Air quality has been discussed for some time among the scientific community. Air pollution in the external environment and that of the indoor environment have been caused for concern. Volatile organic compounds (VOCs) are ...
Efeitos do tratamento com ácido gálico sobre parâmetros oxidativos, moleculares e comportamentais induzidos por cetamina em ratos
(Universidade Federal de Santa Maria, 2019-12-20)
Ketamine is a dissociative anesthetic drug, which blocks NMDA glutamatergic receptors for restricted clinical use due to its high addictive potential. Studies have shown neurotoxicity and memory impairments development ...
Participação do receptor TRPA1 na nocicepção observada em um modelo de esclerose múltipla progressiva em camundongos
(Universidade Federal de Santa Maria, 2020-03-25)
Central neuropathic pain (CNP) is a common untreated symptom in progressive multiple sclerosis (PMS) and is associated with poor quality of life and interference with patients’ daily activities. The neuroinflammation process ...
Avaliação do papel do receptor para tromboxanos (TP) durante a epileptogênese
(Universidade Federal de Santa Maria, 2020-03-05)
Convulsive status epilepticus (SE) is a medical emergency that can lead to epilepsy, long lasting brain damage and death. It is known that there is a strong link between epilepsy and inflammation. For instance, it has been ...
Avaliação de biomarcadores inflamatórios e da atividade da adenosina deaminase e dipeptidil peptidase IV em linfócitos de pacientes com diabetes melito tipo 2
(Universidade Federal de Santa Maria, 2010-12-10)
Diabetes mellitus is a metabolic disease characterized by hyperglycemia due defective or deficient response to insulin secretion. Type 2 diabetes mellitus (Type 2 DM) is therefore associated with a general activation of ...
Avaliação neuropsicológica e dos marcadores inflamatórios nos pacientes com epilepsia
(Universidade Federal de Santa Maria, 2015-08-31)
The epilepsy is a neurological disorder manifested by recurrent unprovoked
seizures, resulting in harmful effects on the patients. Epileptic seizures are generated
from hypersincronic abnormal discharges of neurons, ...
Avaliação da atividade antinociceptiva do extrato bruto, das frações e dos compostos obtidos de Geissospermum vellosii
(Universidade Federal de Santa Maria, 2008-11-04)
The present study examined the antinociceptive effects of Geissospermum vellosii in chemical
behavioral models of nociception. G. vellosii crude extract, dichloromethane fraction (1-100
mg/kg), or aspidospermine (0.001-1 ...