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Análise dos efeitos da indometacina na infecção por SARS-CoV-2 e na resposta inflamatória associada ao sistema purinérgico
(Universidade Federal de Santa Maria, 2023-03-31)
Indomethacin (INDO) reduces SARS-CoV replication in vitro and in vivo, but its effects
against SARS-CoV-2 are poorly known. In addition to possible direct antiviral effects, we
hypothesized that INDO could also modulate ...
Selegilina reverte a piora da memória inuzida por Aβ25-35 em camundongos: envolvimento da atividade da MAO-B
(Universidade Federal de Santa Maria, 2013-02-28)
Alzheimer s disease (AD) is biochemically characterized by the occurrence of extracellular deposits of amyloid beta peptide (Aβ) and intracellular deposits of the hyperphosphorylated tau protein, which are causally related ...
Susceptibilidade in vitro de isolados de Pythium insidiosum frente a aminoglicosídeos e tigeciclina
(Universidade Federal de Santa Maria, 2012-03-15)
Pythiosis is a chronic disease that affects humans, other mammals and birds. It is caused by the
aquatic oomycete Pythium insidiosum. Pythiosis progresses rapidly and can become life
threatening if not treated in the ...
Influência de diferentes ácidos graxos sobre parâmetros comportamentais e oxidativos em ratos submetidos ao estresse agudo
(Universidade Federal de Santa Maria, 2013-08-30)
The fatty acids (FA) are important constituents of brain phospholipid membranes and play important roles in the central nervous system (CNS) may modify the plasticity and fluidity, and act decisively in the development of ...
Envolvimento do receptor de potencial transitório A1 (TRPA1) em um modelo de dor neuropática mantida pelo simpático em camundongos
(Universidade Federal de Santa Maria, 2012-05-26)
Some forms of neuropathic pain are maintained by sympathetic fibers, but the underlying mechanisms are poorly understood. Thus, the aim of this study was to investigate the possible involvement of the TRPA1 receptor as ...
Hormônio alfa estimulante dos melanócitos (α-MSH) não modifica as convulsões induzidas por pentilenotetrazol e por pilocarpina em camundongos
(Universidade Federal de Santa Maria, 2013-11-26)
Alpha-melanocyte stimulating hormone (α-MSH) is a pro-opiomelanocortin (POMC)-derived peptide involved in different neurological functions that also exerts anti-inflammatory effects, including in the central nervous system ...
Envolvimento das poliaminas no ataque agudo de gota em camundongos
(Universidade Federal de Santa Maria, 2016-02-26)
Gout attack is characterized severe joint pain and inflammation with concomitant accumulation of monosodium urate (MSU) crystals. However, gout and the mechanisms responsible for the acute attacks are poorly understood, ...
Efeitos comportamentais e endócrinos da exposição na fase embrionária ao etonogestrel em peixe-zebra
(Universidade Federal de Santa Maria, 2023-09-18)
Improper disposal of expired drugs directly into the garbage or sewage systems
without specific treatment increases concentration of these components in wastewater.
Waste from pharmaceutical industries, used in research ...
Avaliação da influência da dieta em parâmetros de estresse oxidativo, inflamação e modificações epigenéticas em pacientes com lúpus eritematoso sistêmico
(Universidade Federal de Santa Maria, 2023-10-11)
Exacerbated cellular activation due to autoimmunity in Systemic Lupus Erythematosus (SLE)
can generate an imbalance between antioxidants and pro-oxidants, triggering oxidative stress.
In addition to oxidative stress, ...
Efeito do resveratrol per se e associado à cetamina: avaliação comportamental e de marcadores bioquímicos em camundongos
(Universidade Federal de Santa Maria, 2023-12-04)
Schizophrenia is a serious and chronic mental illness, which affects approximately 1% of the
world's population. It is characterized by positive, negative and cognitive symptoms, which
are associated to hyperactivation ...