Methylmalonic acidemias comprehend a group of innate error of the metabolism (EIM)characterized clinically and biochemically for the tissue accumulation of acid methylmalonic (MMA)and neurological dysfunction, including ...

Resveratrol (RES) is an anti-aging molecule that provides both anti-inflammatory and antioxidant properties. However, it is unclear whether the basal oxidative state of the cell has any influence on the effects of this ...

The epilepsy is a neurological disorder manifested by recurrent unprovoked seizures, resulting in harmful effects on the patients. Epileptic seizures are generated from hypersincronic abnormal discharges of neurons, ...

The assessment of biomarkers of reactions involving reactive oxygen species have the potential not only to determine the extent of oxidative damage, but also to predict the effectiveness of therapeutic strategies aimed at ...

Gout attack is characterized severe joint pain and inflammation with concomitant accumulation of monosodium urate (MSU) crystals. However, gout and the mechanisms responsible for the acute attacks are poorly understood, ...

Stroke occurs when blood flow to the brain is interrupted by an embolic or thrombotic occlusion of a cerebral artery (ischemic stroke) or by bleeding from a ruptured blood vessel (hemorrhagic stroke). Oxidative stress and ...

Rosuvastatin is used as a drug of first choice in treating hypercholesterolemia due to competitive inhibition of HMG-CoA reductase enzyme which converts HMG-CoA to mevalonic acid which is the rate-limiting step in ...