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Neurotoxidade Neonatal do Metilmalonato é suficiente para iniciar déficit de memória em camundongos: envolvimento de marcadores inflamatórios e apoptóticos
(Universidade Federal de Santa Maria, 2014-06-28)
The methylmalonic acidemia is an inborn error of metabolism (IEM) characterized by methylmalonic acid (MMA) accumulation in body fluids and tissues, causing neurological dysfunction, mitochondrial failure, oxidative stress ...
Envolvimento do sistema opióide na dependência de estado induzida pela arcaína em ratos
(Universidade Federal de Santa Maria, 2011-03-02)
Arcaine is a competitive antagonist of the polyamine binding site at the NMDA receptor which induces state-dependent recall. However, no study has addressed the involvement of other neurotransmitter/neuromodulators ...
Espermina reverte o dano de memória induzido por lipopolissacarídeo em camundongos
(Universidade Federal de Santa Maria, 2014-08-21)
Neuroinflammation is a neuropathological finding in a number of neurodegenerative diseases. Intraperitoneal injection of lipopolysaccharide (LPS) induces neuroinflammation and memory deficit. Spermine and spermidine are ...
Avaliação neuropsicológica e dos marcadores inflamatórios nos pacientes com epilepsia
(Universidade Federal de Santa Maria, 2015-08-31)
The epilepsy is a neurological disorder manifested by recurrent unprovoked
seizures, resulting in harmful effects on the patients. Epileptic seizures are generated
from hypersincronic abnormal discharges of neurons, ...
Beta-cariofileno atenua dano cognitivo induzido pela exposição ao aspartame em ratos pela modulação da atividade da acetilcolinesterase e da Via BDNF/TrKB
(Universidade Federal de Santa Maria, 2021-08-26)
Aspartame (ASP) is a widely used as a tabletop sweetener and sucrose substitute in many
food matrices. However, several studies have reported that exposure to ASP can damage
biological tissues, such as the central nervous ...
Selegilina reverte a piora da memória inuzida por Aβ25-35 em camundongos: envolvimento da atividade da MAO-B
(Universidade Federal de Santa Maria, 2013-02-28)
Alzheimer s disease (AD) is biochemically characterized by the occurrence of extracellular deposits of amyloid beta peptide (Aβ) and intracellular deposits of the hyperphosphorylated tau protein, which are causally related ...