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Influência farmacogenética da enzima SOD2 na resposta in vitro ao resveratrol de células mononucleares
(Universidade Federal de Santa Maria, 2014-10-03)
Resveratrol (RES) is an anti-aging molecule that provides both anti-inflammatory and antioxidant properties. However, it is unclear whether the basal oxidative state of the cell has any influence on the effects of this ...
Frutose-1,6-bisfosfato e N-acetilcisteína atenuam a formação de produtos proteicos de oxidação avançada, uma nova classe de mediadores inflamatórios, in vitro
(Universidade Federal de Santa Maria, 2012-09-19)
The assessment of biomarkers of reactions involving reactive oxygen species have the
potential not only to determine the extent of oxidative damage, but also to predict the
effectiveness of therapeutic strategies aimed ...
Prostaglandina E2 potencializa as convulsões induzidas por metilmalonato
(Universidade Federal de Santa Maria, 2009-11-23)
Methylmalonic acidemias comprehend a group of innate error of the metabolism (EIM)characterized clinically and biochemically for the tissue accumulation of acid methylmalonic (MMA)and neurological dysfunction, including ...
Avaliação da exposição in vivo ao formaldeído sobre parâmetros do estresse oxidativo, inflamação e modificações epigenéticas
(Universidade Federal de Santa Maria, 2020-10-23)
Air quality has been discussed for some time among the scientific community. Air pollution in the external environment and that of the indoor environment have been caused for concern. Volatile organic compounds (VOCs) are ...
Avaliação do papel do receptor para tromboxanos (TP) durante a epileptogênese
(Universidade Federal de Santa Maria, 2020-03-05)
Convulsive status epilepticus (SE) is a medical emergency that can lead to epilepsy, long lasting brain damage and death. It is known that there is a strong link between epilepsy and inflammation. For instance, it has been ...
Avaliação neuropsicológica e dos marcadores inflamatórios nos pacientes com epilepsia
(Universidade Federal de Santa Maria, 2015-08-31)
The epilepsy is a neurological disorder manifested by recurrent unprovoked
seizures, resulting in harmful effects on the patients. Epileptic seizures are generated
from hypersincronic abnormal discharges of neurons, ...
Efeito in vitro do haloperidol e risperidona na ativação inflamatória de macrófagos RAW 264.7
(Universidade Federal de Santa Maria, 2015-04-10)
Introduction: Antipsychotic drugs, such as haloperidol (typical) and risperidone (atypical)
increase the risk of obesity and other endocrine disturbs in psychiatric patients when used in
long term treatments. There is ...
A aplicação tópica de um antagonista TRPA1 reduz a nocicepção e a inflamação em um modelo de lesão muscular traumática em ratos
(Universidade Federal de Santa Maria, 2023-02-15)
Musculoskeletal pain is a widely experienced public healthcare issue, especially after
traumatic muscle injury. Besides, it is a common cause of disability, but this type of
pain remains poorly managed. However, the ...
Avaliação da influência da dieta em parâmetros de estresse oxidativo, inflamação e modificações epigenéticas em pacientes com lúpus eritematoso sistêmico
(Universidade Federal de Santa Maria, 2023-10-11)
Exacerbated cellular activation due to autoimmunity in Systemic Lupus Erythematosus (SLE)
can generate an imbalance between antioxidants and pro-oxidants, triggering oxidative stress.
In addition to oxidative stress, ...
Envolvimento das poliaminas no ataque agudo de gota em camundongos
(Universidade Federal de Santa Maria, 2016-02-26)
Gout attack is characterized severe joint pain and inflammation with concomitant accumulation of monosodium urate (MSU) crystals. However, gout and the mechanisms responsible for the acute attacks are poorly understood, ...