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Associação da via inflamatória e apoptótica na patofisiologia do acidente vascular encefálico tardio: relação com a dislipidemia
(Universidade Federal de Santa Maria, 2015-01-22)
Stroke occurs when blood flow to the brain is interrupted by an embolic or thrombotic occlusion of a cerebral artery (ischemic stroke) or by bleeding from a ruptured blood vessel (hemorrhagic stroke). Oxidative stress and ...
Efeito farmacogenético do polimorfismo Ala16Val do gene da MnSOD na resposta de pacientes hipercolesterolêmicos a rosuvastatina
(Universidade Federal de Santa Maria, 2015-02-27)
Rosuvastatin is used as a drug of first choice in treating hypercholesterolemia due to
competitive inhibition of HMG-CoA reductase enzyme which converts HMG-CoA to
mevalonic acid which is the rate-limiting step in ...
Influência farmacogenética da enzima SOD2 na resposta in vitro ao resveratrol de células mononucleares
(Universidade Federal de Santa Maria, 2014-10-03)
Resveratrol (RES) is an anti-aging molecule that provides both anti-inflammatory and antioxidant properties. However, it is unclear whether the basal oxidative state of the cell has any influence on the effects of this ...
Frutose-1,6-bisfosfato e N-acetilcisteína atenuam a formação de produtos proteicos de oxidação avançada, uma nova classe de mediadores inflamatórios, in vitro
(Universidade Federal de Santa Maria, 2012-09-19)
The assessment of biomarkers of reactions involving reactive oxygen species have the
potential not only to determine the extent of oxidative damage, but also to predict the
effectiveness of therapeutic strategies aimed ...
Avaliação neuropsicológica e dos marcadores inflamatórios nos pacientes com epilepsia
(Universidade Federal de Santa Maria, 2015-08-31)
The epilepsy is a neurological disorder manifested by recurrent unprovoked
seizures, resulting in harmful effects on the patients. Epileptic seizures are generated
from hypersincronic abnormal discharges of neurons, ...
Efeito da casca de jabuticaba (Myrciaria jaboticaba (Vell.) Berg.) sobre estresse oxidativo e resposta inflamatória em modelo de diabetes mellitus tipo 2 em ratos
(Universidade Federal de Santa Maria, 2014-03-14)
Type 2 diabetes mellitus (DM2) is a multifactorial disease mainly characterized by metabolic disorders related to insulin. Hyperglycemia is one of the causes of excessive generation of reactive oxygen species (ROS) leading ...
Efeito in vitro do haloperidol e risperidona na ativação inflamatória de macrófagos RAW 264.7
(Universidade Federal de Santa Maria, 2015-04-10)
Introduction: Antipsychotic drugs, such as haloperidol (typical) and risperidone (atypical)
increase the risk of obesity and other endocrine disturbs in psychiatric patients when used in
long term treatments. There is ...
Envolvimento das poliaminas no ataque agudo de gota em camundongos
(Universidade Federal de Santa Maria, 2016-02-26)
Gout attack is characterized severe joint pain and inflammation with concomitant accumulation of monosodium urate (MSU) crystals. However, gout and the mechanisms responsible for the acute attacks are poorly understood, ...