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Efeitos do disseleneto de difenila na atividade da enzima δ-aminolevulinato desidratase e em parâmetros bioquímicos de ratos com diabetes mellitus tipo 1
(Universidade Federal de Santa Maria, 2004-07-16)
The hyperglycemia and oxidative stress are factors strongly involved on development of many disorders that characterize the Diabetes Mellitus. It is known that some organic and inorganic selenium compounds are potent ...
Os efeitos de organocalcogêneos e de 2,3-dimercaptopropanol sobre convulsão química e letalidade induzidas por pentilenotetrazol e 4-aminopiridina em camundongos
(Universidade Federal de Santa Maria, 2007-08-17)
Experimental models of seizure in animals have represented an important role for the understanding of the physiological and behavioural alterations associated with the human epilepsy. The induction of partial or generalized ...
Avaliação do desgaste promovido pela broca post preparation utilizando imagens de TCCB
(Universidade Federal de Santa Maria, 2005-01-03)
Several metals are known to disturb cellular functions by binding to thiol groups of biomolecules. Therefore, a possible therapy for metal intoxication is to remove the toxic metals from the bound functional bioligands by ...
Atividade hipolipidêmica do disseleneto de difenila na hiperlipidemia induzida por Triton WR-1339 em camundongos
(Universidade Federal de Santa Maria, 2009-11-26)
In mammals, the liver plays a central role in whole-body lipid metabolism. Unfortunately, dysregulation of these pathways has been implicated in hyperlipidemias. In recent years, a significant association between the trace ...
Mecanismos envolvidos no efeito antioxidante do disseleneto de difenila no dano oxidativo causado pela exposição à fumaça do cigarro em ratos jovens
(Universidade Federal de Santa Maria, 2009-09-09)
Cigarette smoking is a complex mixture of many constituents identified, among them reactive substances (reactive oxygen and nitrogen species), which are capable of initiating or promoting oxidative damage. Lungs and brain ...
Efeito de antioxidantes sobre os níveis de metalotioneínas em camundongos tratados com cloreto de mercúrio
(Universidade Federal de Santa Maria, 2006-02-23)
In this study, acute effects of mercury on mouse blood, kidneys and liver were evaluated. Mice received a single dose of mercuric chloride (HgCl2 - 4.6 mg/kg, subcutaneously) for three consecutive days. We investigated the ...
Alterações comportamentais e neuroquímicas causadas por compostos orgânicos de selênio
(Universidade Federal de Santa Maria, 2006-11-22)
Selenium organic compounds, ebselen and diphenyl diselenide (PhSe)2, are considered mimics of glutathione peroxidase enzyme and present antioxidants and anti-inflammatory properties in different models of brain injury. In ...
Disseleneto de difenila: um organocalcogênio com baixa toxicidade em não roedores e importantes propriedades anti-aterogênicas em modelos in vivo e in vitro
(Universidade Federal de Santa Maria, 2007-06-01)
Atherosclerosis is a chronic inflammatory condition associated with an overproduction of oxidant species. Since low density lipoprotein (LDL) oxidation plays a key role in the pathogenesis of atherosclerosis, antioxidants ...
Efeito de compostos orgânicos de selênio em modelos experimentais de câncer e diabetes mellitus
(Universidade Federal de Santa Maria, 2006-03-16)
This study was designed to determine the effect of organoselenium compounds on experimental models of cancer and diabetes. In mammary carcinogenesis induced by N-nitroso-N-methylurea (NMU, 3 doses of 50 mg/kg, i.p.), it ...
Efeitos da exposição materna ou paterna ao disselento de difenila sobre o desenvolvimento intra-uterino da prole de ratas wistar
(Universidade Federal de Santa Maria, 2006-07-27)
Selenium (Se) is an essential trace element for man and is known for its role in regulating growth and development of the fetus and newborn. Furthermore, Se is a micronutrient required for normal spermatogenesis and, ...