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Mecanismos envolvidos nos efeitos do seleneto vinílico bis substituído (svbs) em modelos animais de depressão e de dor
(Universidade Federal de Santa Maria, 2011-03-18)
The association between depression and chronic pain is frequent and bidirectional. The high number of patients with depression and chronic pain who are refractory to currently available drugs makes it important search for ...
A influência do processo inflamatório nas convulsões e no déficit cognitivo induzidos pelo ácido glutárico em ratos jovens
(Universidade Federal de Santa Maria, 2011-02-04)
Glutaric acidemia type I (GA-I) is an inborn error of metabolism (EIM), characterized biochemically by major accumulation of glutaric acid (GA) and pathologically by a characteristic striatal degeneration. The clinical ...
Avaliação toxicológica de compostos orgânicos de telúrio sobre o desenvolvimento pré-natal em camundongos
(Universidade Federal de Santa Maria, 2011-03-25)
It is known that most chemical agents readily cross the placenta and thus may be considered that maternal exposure to external agents can result in toxic effects on embryo-fetal organism. Considering the chemical characteristics ...
Investigação da atividade antioxidante in vitro e da composição química de diferentes extratos de plantas medicinais
(Universidade Federal de Santa Maria, 2011-03-18)
Oxidative stress (OS) is involved in the development of several disorders involving the central nervous system, such as Alzheimer s disease (AD). Considering the limitations of current therapeutics for AD, there is still ...
Envolvimento do sistema da tiorredoxina nas alterações induzidas pelo chumbo in vitro e in vivo: implicações na toxicidade do chumbo
(Universidade Federal de Santa Maria, 2011-11-30)
Oxidative stress is an important molecular mechanism of lead (Pb) toxicity. The thioredoxin
system (selenoenzyme thioredoxin reductase-TrxR, thioredoxin protein- Trx and NADPH) is essential
for the antioxidant defense ...
Efeito antioxidante da creatina não protege da suscetibilidade à convulsões após traumatismo crânioencefálico em ratos
(Universidade Federal de Santa Maria, 2011-04-06)
Studies over recent years have highlighted the important role of creatine in health and in treating various neurological diseases. However, its role in secondary damage induced by traumatic brain injury (TBI) is not fully ...
Avaliação dos efeitos biológicos do (s) (3-feniltelanil propanamida) succinato de dimetila, um novo telúrio aminoácido derivado do ácido aspártico
(Universidade Federal de Santa Maria, 2011-03-25)
Recent studies from our group demonstrated that the (S)-dimethyl 2-(3-(phenyltellanyl) propanamido) succinate compound, a telluroamino acid showed glutathione peroxidase (GPx)-like activity, attesting to its antioxidant ...
Efeito de Paullinia cupana (Mart.) no estresse oxidativo induzido pelo nitroprussiato de sódio em celúlas de fibroblastos embrionários NIH-3T3
(Universidade Federal de Santa Maria, 2011-04-25)
The antioxidant effects of the hydro-alcoholic guaraná extracts (Paullinia cupana var. sorbilis
Mart.) on nitric oxide (NO ) and other compounds generated from degradation of Sodium
Nitroprusside (SNP) in embryonic ...
Avaliação, in vitro, dos parâmetros cinéticos da enzima acetilcolinesterase cerebral de ratos frente a alguns compostos azóis
(Universidade Federal de Santa Maria, 2011-09-09)
The acetylcholinesterase enzyme is responsible for the acetylcholine
hydrolisis in the synaptic cleft during the transmission of nervous impulse. The
investigation of new inhibitors of this important enzyme is very ...
Caracterização do esteróide α-espinasterol como um novo antagonista do receptor TRPV1 com efeito antinociceptivo
(Universidade Federal de Santa Maria, 2011-09-01)
The transient receptor potential vanilloid 1 (TRPV1) is relevant to the
perception of noxious information and has been studied as a therapeutic target for
the development of new analgesics. The goal of this study was to ...