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Dano ao DNA no diabetes tipo 2 e sua associação com inflamação, estresse oxidativo, disfunção endotelial, resistência à insulina e à ocorrência de complicações crônicas microvasculares
(Universidade Federal de Santa Maria, 2016-03-15)
Several pathophysiological mechanisms are associated with type 2 diabetes mellitus (type 2 DM), such as glucotoxicity, insulin resistance, inflammation, oxidative stress and endothelial dysfunction, which can result in DNA ...
Atividade anticonvulsivante do óleo de peixe
(Universidade Federal de Santa Maria, 2010-08-18)
Methylmalonic acidemias are inherited metabolic disorders characterized by methylmalonate (MMA) accumulation and neurological dysfunction, including seizures. Dietary fatty acids are known as an important energy source and ...
Potencial antiaterogênico da bixina in vivo e in vitro
(Universidade Federal de Santa Maria, 2016-08-25)
Atherosclerosis is a chronic disease characterized by the accumulation of lipids and fibrous elements in the
intima layer of medium and large caliber arteries. Inflammation, oxidative stress as well as low density
lipoprotein ...
Efeitos da oxima butano-2,3-dionatiossemicarbazona frente ao dano testicular causado por cádmio em camundongos
(Universidade Federal de Santa Maria, 2014-03-06)
We investigated the action of butane-2,3-dione thiosemicarbazone oxime against the testicular damage caused by cadmium chloride (CdCl2) in mice swiss adult male. The animals received a single injection of CdCl2 at the dose ...
Influência farmacogenética da enzima SOD2 na resposta in vitro ao resveratrol de células mononucleares
(Universidade Federal de Santa Maria, 2014-10-03)
Resveratrol (RES) is an anti-aging molecule that provides both anti-inflammatory and antioxidant properties. However, it is unclear whether the basal oxidative state of the cell has any influence on the effects of this ...
Frutose-1,6-bisfosfato e N-acetilcisteína atenuam a formação de produtos proteicos de oxidação avançada, uma nova classe de mediadores inflamatórios, in vitro
(Universidade Federal de Santa Maria, 2012-09-19)
The assessment of biomarkers of reactions involving reactive oxygen species have the
potential not only to determine the extent of oxidative damage, but also to predict the
effectiveness of therapeutic strategies aimed ...
Avaliação de biomarcadores associados à inflamação e ao estresse oxidativo em pacientes com câncer de próstata
(Universidade Federal de Santa Maria, 2013-01-28)
Changes in recent decades in morbidity and mortality of prostate cancer (CAP) is
making if a public health problem in several countries, including Brazil. Several studies
provide evidence that inflammatory processes and ...
Avaliação da exposição in vivo ao formaldeído sobre parâmetros do estresse oxidativo, inflamação e modificações epigenéticas
(Universidade Federal de Santa Maria, 2020-10-23)
Air quality has been discussed for some time among the scientific community. Air pollution in the external environment and that of the indoor environment have been caused for concern. Volatile organic compounds (VOCs) are ...
Avaliação do papel do receptor para tromboxanos (TP) durante a epileptogênese
(Universidade Federal de Santa Maria, 2020-03-05)
Convulsive status epilepticus (SE) is a medical emergency that can lead to epilepsy, long lasting brain damage and death. It is known that there is a strong link between epilepsy and inflammation. For instance, it has been ...
Avaliação neuropsicológica e dos marcadores inflamatórios nos pacientes com epilepsia
(Universidade Federal de Santa Maria, 2015-08-31)
The epilepsy is a neurological disorder manifested by recurrent unprovoked
seizures, resulting in harmful effects on the patients. Epileptic seizures are generated
from hypersincronic abnormal discharges of neurons, ...