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Ação convulsivante do disseleneto de difenila em ratos: estudo dos mecanismos neuroquímicos e da toxicocinética
(Universidade Federal de Santa Maria, 2010-07-27)
In recent years have been identifical numerous pharmacological properties of a selenium compound, diphenyl diselenide [(PhSe)2]. Consequently, it is important the investigation of its toxic effect for a safe application ...
Polimorfismo da Ala16Val MnSOD na hipercolesterolemia e sua associação com biomarcadores de inflamação e estresse oxidativo
(Universidade Federal de Santa Maria, 2010-03-11)
This study aimed to analyze the association between the genetic polymorphism of the manganese-dependent superoxide dismutase (Ala16Val MnSOD) and the oxidative and inflammatory markers in hypercholesterolemic and control ...
Respostas bioquímicas e fisiológicas de Cucumis sativus e Avena sativa ao estresse causado por alumínio
(Universidade Federal de Santa Maria, 2010-05-21)
Aluminum (Al) is the most abundant metal in the Earth's crust, affecting growth and development of plants. The aim of this study was to investigate the effects of Al on
seedlings of cucumber (Cucumis sativus L.) and oat ...
Estudo de mecanismos de toxicidade do metilmercúrio: papel protetor de flavonóides
(Universidade Federal de Santa Maria, 2010-08-12)
Methylmercury (MeHg) is an important environmental toxicant that may cause irreversible neurobehavioral and neuropsychological disorders in humans and experimental animals. The major mechanisms of MeHg-induced toxicity ...
Efeitos da crioterapia em modelos de contusão e isquemia/reperfusão sanguínea em músculo de ratos
(Universidade Federal de Santa Maria, 2010-12-16)
The musculoskeletal disorders are in the most common injuries observed in individuals in the primary care, occupational health, and in sports medicine. Among these disorders, the contusion is described as a direct traumatic ...
Atividade antioxidante e hepatoprotetora de plantas brasileiras, contendo compostos fenólicos.
(Universidade Federal de Santa Maria, 2010-06-07)
Plants from Brazilian flora were chosen and studied for their in vitro and in vivo antioxidant and in vivo hepatoprotetive activity, especially in relation to phenolic compounds which have several health benefits. These ...
Avaliação do potencial antinociceptivo da Mirabilis jalapa L. em camundongos
(Universidade Federal de Santa Maria, 2010-12-09)
The knowledge about the use of medicinal plants by the population contributed decisively to the modern therapy and the discovery of important mechanisms related to the process of transmission and treatment of pain. A plant ...
Validação de método cromatográfico por exclusão molecular para avaliação de interferon-alfa2a e estudos de correlação
(Universidade Federal de Santa Maria, 2010-09-30)
Human interferon-α2a (hIFN-α2a) is a natural protein produced by the cells of the immune system with antiviral, antiproliferative and immunomodulatory properties. A size exclusion liquid chromatography (SE-LC) method was ...
Respostas bioquímicas em carpas (Cyprinus carpio) expostas ao fungicida tebuconazole (folicur® 200 ec)
(Universidade Federal de Santa Maria, 2010-07-22)
The intensive use and/or inadequate management of pesticides have led to contamination of the aquatic ecosystem, reaching the biota living there, including the fish. Pesticides can affect toxicological parameters these ...
Efeito da exposição in vivo ao ditelureto de difenila em camundongos: evidências para estresse oxidativo
(Universidade Federal de Santa Maria, 2010-09-24)
In this work, we investigated the effect of (PhTe)2 administration (10 μmol/kg and 50 μmol/kg) to adult mice on the behavioral performance and on some parameters of oxidative stress in the brain ad liver. The animals ...