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Envolvimento de fatores oxidativos e inflamatórios sobre a resistência ao tratamento com fluoxetina em um modelo de depressão em camundongos
(Universidade Federal de Santa Maria, 2021-10-27)
Major depression (DM) is among the most disabling mental disorders in the world. According to the World Health Organization (WHO), more than 300 million people are affected by DM. The disorder is characterized by a set of ...
Efeito neuroprotetor do JM-20 em ratos submetidos a traumatismo cranioencefálico leve
(Universidade Federal de Santa Maria, 2021-09-10)
Traumatic brain injury (TBI) is a multisystemic pathology with interactions between central nervous system, peripheral nervous system and immune system. It is one of the main causes of death and desability worldwide. The ...
Mecanismos neuroinflamatórios in vitro do alumínio em células microgliais: envolvimento da via de sinalização purinérgica
(Universidade Federal de Santa Maria, 2021-11-09)
Aluminum is a toxic metal to the nervous tissue and an etiological factor of neurodegenerative diseases, particularly Alzheimer's disease (AD). Furthermore, microglial cells and cellular signaling pathways, such as the ...
Efeitos do ácido clorogênico na modulação da sinalização purinérgica e perfil inflamatório em células microgliais expostas ao lipopolissacarídeo
(Universidade Federal de Santa Maria, 2021-09-16)
Neuroinflammation is a process associated with various neurodegenerative diseases, especially Parkinson’s and Alzheimer’s Disease. In the Central Nervous System (CNS), microglial cells are the most important macrophages ...