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Atividade antinociceptiva de derivados 5-trifluormetil-4,5-diidro-1h-pirazol-1-carboxiamida em modelos animais de nocicepção aguda e crônica
(Universidade Federal de Santa Maria, 2008-08-06)
To identify the origin of pain and relieve of it is, certainly, important part of the
treatment of any pathology. Unfortunately, nor all pain modalities possess an
adequate treatment at a moment. Many patients do not obtain ...
Avaliação do potencial antinociceptivo de 5- trialometil- 4,5-diidro-1h- pirazol metil ésteres inéditos em camundongos
(Universidade Federal de Santa Maria, 2008-07-11)
Pain is a common symptom in clinical practice and many advances have been observed in order to obtain more effective analgesic molecules with fewer side
effects. The present study evaluated the antinociceptive potential ...
Avaliação do perfil oxidativo e da atividade de ectoenzimas em pacientes com neoplasia intra-epitelial cervical
(Universidade Federal de Santa Maria, 2008-08-22)
Uterine cancers are considered to be one of the most important malignant diseases of the female genital tract, preceded only by breast cancer. The tumor cells may produce oxidative disturbances as well as damage to the ...
Sistemas purinérgico e colinérgico e perfil oxidativo no encéfalo de roedores: influência do alumínio e de diferentes dietas
(Universidade Federal de Santa Maria, 2008-03-05)
In this study, the effects of Aluminium (Al) and of different diets, both individually and in association, were investigated through the determination of NTPDase, 5 -nucleotidase and acetylcholinesterase (AChE) activities ...
Interaction of organodiselenides with sulphydryl groups at the active sites of some thiol containing proteins - in vitro and in vivo mechanistic studies in mammalian models of diabetes
(Universidade Federal de Santa Maria, 2008-04-02)
The present study sought to compare the in vitro antioxidant potentials of a newly synthesized organodiselenide, dicholesteroyl diselenide (DCDS) and diphenyl diselenide (DPDS) and their possible interactions with some ...
Atividade das ectonucleotidases, colinesterase sérica e perfil oxidativo no diabetes melito tipo 2 e hipertensão em humanos
(Universidade Federal de Santa Maria, 2008-03-05)
The increase in the NTPDase and 5'-nucleotidase enzymatic activities, in patients with diabetes and hypertension, unchained the investigation of the possible mechanisms involved in the alterations in ectonucleotidases ...
Efeito neuroprotetor da creatina e avaliação dos parâmetros cinéticos da captação de glutamato induzidos pelo ácido glutárico no estriado de ratos
(Universidade Federal de Santa Maria, 2008-10-14)
Glutaric acidemia type I (GA-I) is an inborn error of metabolism (EIM) biochemically characterized by the main accumulation of glutaric acid (GA) and 3- hydroxyglutaric acid (3-OH-GA), and pathologically by a characteristic ...
Efeito de 2-aril(heteroaril)-4,5-diidro-1h-imidazóis sobre a atividade da enzima monoamina oxidase in vitro
(Universidade Federal de Santa Maria, 2008-08-05)
Monoamine oxidase (MAO) is a flavin adenine dinucleotide (FAD)-containing enzyme attached to the mitochondrial outer membrane of neurons, glia, and other cells. Its roles include regulation of the levels of biogenic and ...
Análise das propriedades antioxidantes das oximas 3-(fenil hidrazona) butano-2-ona e butano-2,3-dionatiosemicarbazona
(Universidade Federal de Santa Maria, 2008-05-12)
Oximes are chemical compounds used to reactivate the inhibited acetylcholinesterase (AChE) enzyme by organophosphates (OPs). The OPs, besides classically recognized as AChE irreversible inhibitors, are also involved in the ...
Influência do exercício físico sobre parâmetros de comportamento e estresse oxidativo em modelo animal de discinesia tardia
(Universidade Federal de Santa Maria, 2008-03-07)
Regular practice of physical activity promotes beneficial effects to the body. However, excessive duration and intensity of exercise may surpass individual tolerance to
exercise, generating oxidative stress (OS). Studies ...