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Interaction of organodiselenides with sulphydryl groups at the active sites of some thiol containing proteins - in vitro and in vivo mechanistic studies in mammalian models of diabetes
(Universidade Federal de Santa Maria, 2008-04-02)
The present study sought to compare the in vitro antioxidant potentials of a newly synthesized organodiselenide, dicholesteroyl diselenide (DCDS) and diphenyl diselenide (DPDS) and their possible interactions with some ...
Poliaminas modulam a memória nas tarefas de medo condicionado e esquiva inibitória em ratos
(Universidade Federal de Santa Maria, 2004-09-03)
The polyamines, spermine, spermidine and putrescine, are a group of aliphatic amines that interact with diverse cellular targets such as nucleic acids and proteins. The polyamines may act as physiological modulators of ...
Sobre a excitotoxicidade induzida por glutamato em retina embrionária de pinto
(Universidade Federal de Santa Maria, 2004-08-20)
Excitotoxicity refers to the neurodegenerative process initiated by excessive activation of receptors for the neurotransmitter glutamate. This process is one of the
most extensively studied processes of neuronal cell death, ...
Efeitos do herbicida clomazone sobre parâmetros metabólicos e antioxidantes em jundiá (Rhamdia quelen)
(Universidade Federal de Santa Maria, 2004-09-10)
The objective of this study was to evaluate the effect of clomazone herbicide on metabolism of silver catfish (Rhamdia quelen). It was measured levels of lactate, protein and glucose (plasma), glycogen, protein and lactate ...
Quantificação da glutationa reduzida em eritrócitos humanos por cromatografia líquida de alta eficiência-uv: validação e aplicação
(Universidade Federal de Santa Maria, 2005-02-21)
Oxidative stress may be initiated by a decline in the antioxidant defence system or by an overproduction of free radicals leading to an imbalance between oxidants and antioxidants. The most significant alteration in the ...
Derivados pirazolínicos inéditos causam antinocicepção em camundongos no teste da formalina
(Universidade Federal de Santa Maria, 2004-07-29)
The discovery of pyrazole derivatives dates back to 1884, when the German chemist Ludwig Knorr attempted to synthesize quinoline derivatives with antipyretic activity and accidentally obtained antipyrine, a pyrazolinone, ...
β-nadh diminui a sensibilidade da sucinato desidrogenase a inibição por ácido metilmalônico
(Universidade Federal de Santa Maria, 2007-05-04)
Methylmalonic acidemia, one of the most frequent organic acidemias, is caused by deficiency of the methylmalonyl CoA mutase, leading to tissue accumulation of Lmethylmalolonic acid (MMA). Affects individuals present lethargy, ...
Efeito agudo e crônico do etanol sobre as enzimas NTPDase, 5'-nucleotidase, acetilcolinesterase, peroxidação lipídica e comportamento em ratos
(Universidade Federal de Santa Maria, 2004-10-15)
Ethanol is one of the most used substance in different societies. This study was
performed in order to clarify the acute and chronic effects of ethanol on biochemical
and behavioral parameters in male Wistar rats. The ...
Efeito da administração aguda de creatina sobre a memória em ratos
(Universidade Federal de Santa Maria, 2005-04-08)
Glucose is the most important energy substrate for the central nervous system. Besides its energetic function, glucose facilitates memory in experimental animals, an effect that has been related to its energy functions. ...
Óxido nítrico modula a melhora da memória induzida por espermidina em ratos
(Universidade Federal de Santa Maria, 2006-12-06)
The endogenous poliaminas, putrescine, spermidina and spermine are aliphatics amines that are present in high concentrations in the central nervous system (SNC). The action of the poliamines involves the modulation of ...