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Derivados pirazolínicos inéditos causam antinocicepção em camundongos no teste da formalina
(Universidade Federal de Santa Maria, 2004-07-29)
The discovery of pyrazole derivatives dates back to 1884, when the German chemist Ludwig Knorr attempted to synthesize quinoline derivatives with antipyretic activity and accidentally obtained antipyrine, a pyrazolinone, ...
Efeito hiperalgésico produzido pela administração de bradicinina na amígdala de ratos
(Universidade Federal de Santa Maria, 2006-08-31)
The peptide bradykinin is one of the most potent algogenic substances and its role in nociception has been intensively studied in the peripheral nervous system. However,
its action in pain transmission in central nervous ...