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Análise de biomarcadores em jundiás (Rhamdia quelen) expostos in situ como uma ferramenta de avaliação ambiental
(Universidade Federal de Santa Maria, 2017-03-24)
Aquatic ecosystems are affected by the use of agrochemicals in agricultural areas near rivers. To evaluate possible impacts, studies with animals that inhabit these ecosystems are needed. In situ exposure is one way of ...
Consumo de mel fornece proteção contra alterações motoras e moleculares induzidas por hipóxia/reperfusão em Drosophila melanogaster
(Universidade Federal de Santa Maria, 2017-02-14)
Honey is a complex product produced by honeybees from nectar, being widely used for its sweetening properties, as well as for its benefits to human health. Honey presents anti-inflammatory, hypoglycemic and antioxidant ...
Associação do polimorfismo MnSOD ALA16VAL com os biomarcadores inflamatórios, apoptóticos e BDNF em pacientes após acidente vascular encefálico tardio
(Universidade Federal de Santa Maria, 2017-07-01)
Stroke is one of the most frequent neurologic diseases and involves various risk factors such as atherosclerosis, dyslipidemia and diabetes mellitus. Furthermore, the mechanisms of action associated with the pathophysiology ...
Disseleneto de difenila em modelos de infecção viral causada por herpes simplex vírus dos tipos 1 e 2
(Universidade Federal de Santa Maria, 2017-03-02)
Infectious diseases caused by herpes simplex virus types 1 and 2 (HSV-1 and HSV-2) are among the pathologies that most affect the population. The search for new therapeutic alternatives for its treatment becomes relevant ...
Efeitos da combinação de paracetamol e cafeína sobre a bioenergética mitocondrial em fígado de camundongos
(Universidade Federal de Santa Maria, 2017-07-28)
Paracetamol (acetaminophen, N-acetyl-p-aminofenol, APAP) is a drug with analgesic and antipiretic effects, widely used, presenting low cost, easier aquisition and clinical efficacy. Accidental or intentional use of high ...
Envolvimento dos sistemas purinérgico, colinérgico e estresse oxidativo nos distúrbios da tireoide: possível efeito protetor da quercetina
(Universidade Federal de Santa Maria, 2017-02-22)
Thyroid hormones modulate the metabolic pathways in the body and have important physiological
functions in the brain and vascular system. Changes in their production or distribution lead to disorders
such as hypothyroidism ...
Ação farmacológica do 4,4’-dicloro-difenil disseleneto em modelos de hiperglicemia e obesidade em ratos
(Universidade Federal de Santa Maria, 2017-03-03)
The obesity epidemic is a worldwide public health problem and is considered one of the leading causes of death and disability worldwide. This is because the pathophysiology of this disease is extremely complex and involves ...
Discinesia espontânea em ratos: possível participação de mecanismos oxidativos e dopaminérgicos
(Universidade Federal de Santa Maria, 2017-08-17)
Tardive dyskinesia is a movement disorder that develops as a result of prolonged use of antipsychotics, mainly the typical ones, in approximately 20% to 25% of patients and, as age increases, it afflicts about 50% of ...
Análise do traumatismo cranioencefálico leve sobre a susceptibilidade a pentilenotetrazol e o efeito do pré-tratamento com cafeína em ratos
(Universidade Federal de Santa Maria, 2017-09-19)
Traumatic Brain Injury (TBI) is a public health problem, with a high incidence, debilitation and fatality in modern society, often resulting in neurological dysfunctions. These abnormalities after TBI have been shown to ...
Atividade antitumoral da berberina em células de neuroblastoma SH-SY5Y
(Universidade Federal de Santa Maria, 2017-02-23)
Neuroblastoma is the most common tumor found in the first year of life and represent 6% of the all childhood cancers. There is few options of treatment and the mortality is close to 21%, or exceeds 50% between the high ...