Buscar
Itens para a visualização no momento 1-10 of 20
Resistência de biofilmes formados por micobactérias de crescimento rápido frente a antimicrobianos
(Universidade Federal de Santa Maria, 2018-03-28)
Rapidly growing mycobacteria (RGM) are opportunistic pathogens that produce diseases in a variety of clinical settings. The environmental nature of RGM and their ability to assemble biofilms on different surfaces play a ...
Nanocapsules of the tucumã oil (Astrocaryum vulgare Mart): preparation, characterization, safety evaluation in vitro and in vivo and antitumoral effectiveness in vitro
(Universidade Federal de Santa Maria, 2019-08-23)
Breast cancer is a disease of great molecular complexity and its incidence grows every year.
By 2019 approximately sixty thousand new cases are expected in Brazil, as it generates
concern mainly for women. In view of ...
Desenvolvimento de nanocápsulas para a liberação controlada de crisina: avaliação da atividade antioxidante e da citotoxicidade in vitro
(Universidade Federal de Santa Maria, 2015-09-25)
Chrysin (5,7-dihydroxyflavone) is a flavonoid (class of flavones), which presents antioxidant and antitumoral activities. However, it has low solubility and hence its bioavailability in the body is low, limiting its ...
Desenvolvimento de formas farmacêuticas sólidas e semissólidas contendo piperina associada a nanocarreadores
(Universidade Federal de Santa Maria, 2018-08-17)
The possibility of associating natural actives with nanostructured systems appears as a less invasive
treatment option for the organism. This is because, nanoparticles are able to control the release and
attenuate the ...
Desenvolvimento e avaliação biológica de hidrogel contendo nanocápsulas de óleo de romã e silibinina para o tratamento de danos inflamatórios cutâneos causados pela radiação ultravioleta
(Universidade Federal de Santa Maria, 2017-07-26)
Silibinin (SB) is a flavonoid extracted from the plant Silybum marianum that has been studied as an active substance to protect the skin against damage ultraviolet-induced. Its limited solubility and bioavailability impairs ...
Desenvolvimento de nanocápsulas poliméricas para liberação pulmonar do dipropionato de beclometasona
(Universidade Federal de Santa Maria, 2013-03-22)
Polymeric nanocapsules have been studied extensively for drug delivery by various routes of administration. Currently, the nanoencapsulation of drugs is considered the most efficient means of ensuring controlled release, ...
Desenvolvimento tecnológico de produtos secos redispersíveis a partir de nanoestruturas contendo tioconazol
(Universidade Federal de Santa Maria, 2013-04-29)
Spray-drying and freeze-drying are dehydration techniques which serve as alternative to increase the stability of formulations which are in aqueous medium. Therefore, this study objectived the development of redispersible ...
Sistemas nanoestruturados contendo óleo essencial de Melaleuca alternifolia: desenvolvimento de formulações e atividade biológica
(Universidade Federal de Santa Maria, 2011-08-15)
The aim of this work was the development of nanostructured formulations containing
M. alternifolia essential oil. Polymeric nanocapsules and nanoemulsions (10 mg/mL) were
prepared by the interfacial deposition of preformed ...
Desenvolvimento tecnológico de suspensões e liofilizados de nanocápsulas poliméricas para a veiculação do neuroprotetor idebenona
(Universidade Federal de Santa Maria, 2013-10-30)
Idebenone is an antioxidant, a synthetic derivative of coenzyme Q10, with several applications, such as neuroprotection. However, this drug has low solubility in water, besides is irritant substance and has chemical ...
Formulações nanoestruturadas contendo rutina: desenvolvimento, atividade antioxidante in vitro e efeito sobre a cicatrização cutânea
(Universidade Federal de Santa Maria, 2010-08-16)
This work had as main objective the development of nanostructured formulations
containing rutin, using nanoparticles prepared with alternative vegetables oils. In the first chapter
it was demonstrated the feasibility of ...