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Efeitos metabólicos do consumo da castanha do Brasil (Bertholletia excelsa) em humanos saudáveis
(Universidade Federal de Santa Maria, 2014-02-25)
Brazil nut (Bertholletia excelsa, Lecythidaceae family) is the richest known food in selenium. Its consumption has demonstrated efficient in improving the lipid profile and the plasmatic selenium levels as well as to ...
Ação farmacológica do 3-alquinil selenofeno em modelos de convulsão em ratos jovens
(Universidade Federal de Santa Maria, 2012-03-02)
Seizures have important consequences in terms of mortality and quality of life of the affected population, being a risk factor for the development of cognitive and behavioral abnormalities. Considering the promising ...
Disseleneto de difenila em modelos de infecção viral causada por herpes simplex vírus dos tipos 1 e 2
(Universidade Federal de Santa Maria, 2017-03-02)
Infectious diseases caused by herpes simplex virus types 1 and 2 (HSV-1 and HSV-2) are among the pathologies that most affect the population. The search for new therapeutic alternatives for its treatment becomes relevant ...
Ação farmacológica do 4,4’-dicloro-difenil disseleneto em modelos de hiperglicemia e obesidade em ratos
(Universidade Federal de Santa Maria, 2017-03-03)
The obesity epidemic is a worldwide public health problem and is considered one of the leading causes of death and disability worldwide. This is because the pathophysiology of this disease is extremely complex and involves ...
Disseleneto de m-trifluormetil-difenila modula as adaptações neurotóxicas e comportamentais induzidas pela retirada da morfina em camundongos
(Universidade Federal de Santa Maria, 2019-02-22)
Repeated use of morphine is controversial because it leads to the development of withdrawal syndrome, phenomenon involving a number of neuronal adaptations, which results on manifestations of physical signs and a state ...
Depressão e prejuízo de memória induzidos pela administração de estreptozotocina em camundongos: efeitos terapêuticos do disseleneto de p-clorodifenila
(Universidade Federal de Santa Maria, 2020-02-20)
Pre-diabetes and diabetes are metabolic diseases of heterogeneous etiopathology including defects in
the secretion and action of insulin, or both, the presence of hyperglycemia, glucose and insulin
intolerance, disorders ...
Efeito neuroprotetor do exercício de natação e do disseleneto de m-trifluormetil difenila em um modelo de dieta hipercalórica em camundongos jovens
(Universidade Federal de Santa Maria, 2021-05-21)
The nutrition transition process has generated negative impacts on population health. The increasing consumption of foods and beverages with higher energy density and lower nutritional value promotes damage to the body, ...
Atividade hipolipidêmica do disseleneto de difenila na hiperlipidemia induzida por Triton WR-1339 em camundongos
(Universidade Federal de Santa Maria, 2009-11-26)
In mammals, the liver plays a central role in whole-body lipid metabolism. Unfortunately, dysregulation of these pathways has been implicated in hyperlipidemias. In recent years, a significant association between the trace ...
Modelos de toxicidade da cisplatina em ratos adolescentes: papel protetor do disseleneto de difenila e do ebselen e avaliação da co-exposição ao estresse
(Universidade Federal de Santa Maria, 2022-04-19)
Cisplatin is a recommended chemotherapy drug for the treatment of pediatric and adult
neoplasms that, despite its wide use, is related to numerous serious adverse effects
such as neurotoxicity. In animal models using ...
Atividade antioxidante do e-1,1-metiltio-selenofenil-2-pirrolidinona-hepteno: um composto orgânico de selênio com baixa toxicidade
(Universidade Federal de Santa Maria, 2007-04-20)
The objective of this work was to evaluate the antioxidant activity of (E)-1-(1-(methylthio)-1-selenopheny) hept-1-en-2-yl) pyrrolidin-2-one: an organoselenium compound with low toxicity (compound 1). A number of parameters ...